Pharma Excipients
DC excipient
Typical Physical Attributes of Microcrystalline Cellulose Dried by Spray, Spin Flash and Bulk Drier…
ABSTRACT
The solid dosage form is the easiest method of administering drugs for systemic effect. All dosages forms are made by two main components one is API and second is excipient. Excipient is present in bulk quantity and is required for binding the API. There are mainly two techniques uses for…
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Omya mineral solutions: Easy formulation with multiple benefits
PRESS RELEASE
Oftringen (Switzerland), September 2023 – Manufacturers in the field of pharma and nutraceuticals can step into a new era of uncomplicated and future-proof formulation: With the Omyanutra® range, Suisse mineral expert Omya offers advanced excipients to overcome the challenge of…
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The Guide to Formulating Oral Extended-Release Tablets
Extended-release tablets, also known as sustained-release, controlled-release, or time-release tablets, have become increasingly important in the healthcare sector due to their ability to maintain consistent drug levels in the body over a specific period. This drug delivery system provides various…
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Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed excipient properties. The tablet press was equipped with a…
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Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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Continuous Direct Compression of a High-dose Drug Evaluation of Process and Quality Attributes
Summary
Continuous production has now been adopted even in the pharmaceutical industry and is indispensable in current product developments. This study focuses on the process of continuous direct compression, with the aim of guaranteeing constant product quality over the whole production run. A…
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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression…
Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms (e.g., suitable for direct compression tableting). These…
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Process intensification using a semi-continuous mini-blender to support continuous direct…
The production of pharmaceutical tablets is shifting towards continuous manufacturing. Therefore, individual unit operations such as powder blending need to be re-designed. Continuous powder blending has been implemented successfully, but for low-dose formulations this is challenging due to…
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AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Continuous manufacturing is one of the greatest trends in the pharmaceutical industry, bringing advantages compared to the traditional batch production:
Quality and cost position of the final medicine is improved
Batch-to-batch variations are eliminated
Intermediate storage becomes…
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Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan:…
The study reported here aimed to develop and optimize the S-SNEDDS tablet of bosentan (BOS) and to investigate its pharmacokinetic and biodistribution properties. The BOS-loaded SNEDDS have been developed and characterized in a previous study. The BOS-loaded SNEDDS formulation was converted to…
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