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Diabetes
Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug formulation and wound dressing taking into consideration clinical…
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Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic…
Abstract
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing…
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Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent…
Abstract
The global community is faced with numerous health concerns such as cancer, cardiovascular and neurological diseases, diabetes, joint pain, osteoporosis, among others. With the advancement of research in the fields of materials chemistry and medicine, pharmaceutical technology and…
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Nanoparticles targeting the intestinal Fc receptor enhance intestinal cellular trafficking of…
Semaglutide is the first oral glucagon-like peptide-1 (GLP-1) analog commercially available for the treatment of type 2 diabetes. In this work, semaglutide was incorporated into poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles (NPs) to improve its delivery across the…
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Design, development and scale up studies of metformin hydrochloride multiparticulate system: A…
Metformin hydrochloride (MH) is prescribed for treating diabetes mellitus. The most popular dosage form, viz., tablets has a bulky nature as MH dose ranges up to 1000 mg leading to large size. In geriatric or dysphagic patients, due to altered physiology, swallowing such bulky formulation is…
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Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for…
Objectives
Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the feasibility of a new system ensuring stomach-retention and personalized release of this drug…
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Injectable systems for long-lasting insulin therapy
Abstract
Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4–6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue…
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Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain…
Insulin is classified as a cold chain product due to being a peptide hormone with stability issues in the liquid preparation. Therefore, insulin was developed into the dry powder form to improve the stability and application for nose-to-brain delivery in Alzheimer’s disease treatment. Insulin was…
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A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic…
Since 1922, insulin has saved the lives of countless people. However, the difficulties of subcutaneous administration, the need for frequent glucose self-monitoring, and the non-physiological action profiles of insulin prompted many medical professionals and patients to ask fornon-injectable insulin…
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How a suction cup delivers medications to the bloodstream
Researchers at ETH Zurich have developed a suction cup that allows medications to be absorbed through the mucosal lining of the cheeks. This new approach could spare millions of patients the pain and fear associated with injections.
Many of today’s medications belong to groups of relatively large…
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