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Diabetes
Design of a self-unfolding delivery concept for oral administration of macromolecules
Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due to their degradation in the gastrointestinal tract and low transmucosal permeation. In this study, the concept of an oral delivery device utilizing an elastomeric material is…
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Functionalization of lipid-based formulations for oral delivery of insulin
Insulin is a potent therapeutic molecule used for the treatment of diabetes mellitus type I and late-stage type II. Insulin is usually administered via subcutaneous (s.c.) injection, which bypasses the portal circulation and, in turn, is likely to cause diabetic complications after long-term…
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Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible…
The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases,…
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Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of enteric semipermeable capsule shell and the core prescription…
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Amphiphilic Polyacrylamide Excipients Lead to a Record-Breaking Fast-Acting Insulin
Fast-acting insulins are central to the regulation of prandial glucose in diabetic patients. Current fast-acting insulins require 20–30 min for the onset and longer for the peak blood concentrations. The recent work by Mann et al. used high-throughput synthesis and screening of polyacrylamide-based…
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Transdermal delivery of peptide and protein drugs
Peptide and protein drugs (PPDs) that possess the advantages of high specificity and tolerance, and low immunogenicity can effectively treat diabetes, osteoporosis, cancer, and genetic defects. However, the high molecular weight and poor stability of PPDs lead to low bioavailability in oral delivery…
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Development and evaluation of solid dispersion based rapid disintegrating tablets of poorly…
Glimepiride is an effective oral hypoglycemic agent that lowers the glucose level of blood by stimulating insulin release from beta cells of the pancreas. However, the poor aqueous solubility (i.e., <0.004 mg/ml) and wettability of drugs pose hurdles in the formulation of drug delivery vehicles.…
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Enhanced oral delivery of insulin via the colon-targeted nanocomposite system of organoclay/glycol…
This study aimed to develop a ternary nanocomposite system of organoclay, glycol-chitosan, and Eudragit®S100 as an effective colon targeted drug delivery carrier to enhance the oral absorption of insulin. A nanocomplex of insulin and aminoclay was prepared via spontaneous co-assembly, which was then…
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Semi-Phyto Universal Solubilizer (SPUS) for enhancing solubility and bio availability of Bioactive…
Aqueous Solubility of Bio actives plays a significant role in Drug, Biopharma, Food, Dietary and Cosmetic formulations. Poor solubility is one of the biggest hurdles in developing these formulations as well as desired therapeutic effect. It is well proven that more aqueous soluble means rapid…
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Metformin Hydrochloride- and Glyburide-Containing Orally Disintegrating Tablets
Diabetes is characterized by chronic hyperglycemia. Although metformin hydrochloride (MHCl)- and glyburide (GLB)-containing conventional tablets are available in the market and used to treat diabetes, orally disintegrating tablets (ODTs) containing the combination of these drugs are not commercially…
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