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Diabetes
Electrospinning of natural polymers for the production of nanofibres for wound healing applications
Wound healing is a highly regulated process composed of four overlapping phases: (1) coagulation/haemostasis, (2) inflammation, (3) proliferation and (4) remodelling. Comorbidities such as advanced age, diabetes and obesity can impair natural tissue repair, rendering the wound in a pathological…
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Research and Review of Polymethyl-methacrylate Copolymers in the Development of Enhanced…
The following thesis shall primarily explore the current research regarding the implementation of modifiable microscopic and nanoscopic polymer particles as novel pharmaceutical delivery systems. Polymethacrylate-based copolymers, such as EudragitTM, are sensitive to alterations in pH levels,…
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The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the…
Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin
The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus…
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Bioavailability enhancement of repaglinide from transdermally applied nanostructured lipid carrier…
Repaglinide (RG) is an effective anti-diabetic drug (BCS class II) with limited oral bioavailability < 55% due to poor solubility and high first-pass hepatic metabolism. The aim of the paper was to formulate repaglinide loaded nanostructured lipid carrier-gel (RG-NLCs-gel) system to improve the…
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Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
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Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral…
Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was designed to prepare and optimize PGL loaded solid lipid nanoparticles (SLNs). The formulation was optimized using three factors lipid (Compritol® 888 ATO - A), surfactant…
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Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics,…
Introduction: Solid lipid nanoparticles (SLNs) are considered a promising system in enhancing the oral bioavailability of poorly water-soluble drugs; owing to their intrinsic ability to increase the solubility together with protecting the incorporated drugs from extensive metabolism.
Objective: …
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Encapsulation of an insulin-modified phosphatidylcholine complex in a self-nanoemulsifying drug…
Insulin is a dimeric hormone commonly administered by subcutaneous injection as the primary treatment for diabetes. This strategy, while efficient, does carry potential complications i.e., lipodystrophy with a decrease in absorption and also possible infections, caused by constant injectable…
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Selection Of A Filler For Tablets Manufactured With Direct Compression Method Containing Dry Ginger…
The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II diabetes mellitus.
Aim: To choose the rational…
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DNA scaffold nanoparticles coated with HPMC/EC for oral delivery
The control of the glycemic level among diabetes/T2 patients is very important for their long term survival and avoiding further complexities including micro/macrovascular diseases as well as diabetic neuropathy. Vildagliptin (VD) is a drug that has addressed these issues successfully with the…
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