Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Modelling the Evolution of Pore Structure during the Disintegration of Pharmaceutical Tablets
Pharmaceutical tablet disintegration is a critical process for dissolving and enabling the absorption of the drug substance into the blood stream. The tablet disintegration process consists of multiple connected and interdependent mechanisms: liquid penetration, swelling, dissolution, and break-up.…
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Application of NMP and Neusilin US2-integrated liquisolid technique in mini-tablets for improving…
Frankincense and myrrh are widely used Chinese medicines, showing clinically relevant synergistic therapeutic effects in the treatment of inflammation and cancer. We investigated the applicability of a liquisolid (LS) technique to the preparation of mini-tablets containing supercritical fluid…
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who advances drug delivery? we do. – pharmaceutical product and solution guide by Ashland
advancing drug delivery
Ashland’s pharmaceutical team prides itself on advancing drug delivery with sophisticated science-based solutions. Our global centers of excellence contain the latest equipment and our research scientists and formulators are ready to work with you from concept to…
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Upscaling of external lubrication from a compaction simulator to a rotary tablet press
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction…
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Orally disintegrating drug carriers for paediatric pharmacotherapy
Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several…
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Formulation and Characterisation of Carbamazepine Orodispersible 3D-Printed Mini-Tablets for…
Abstract
One of the main challenges to paediatric drug administration is swallowing difficulties, hindering the acceptability of the medicine and hence clinical outcomes. This study aims at developing a child-appropriate dosage form, the orodispersible mini-tablet (ODMT), using the model drug…
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Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
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Preparation, characterization, and in vitro release of microencapsulated essential oil…
Oregano essential oil (EO)–loaded pellets were prepared using calcium phosphate substrates of different specific surface areas (Sw) and as binders EO in water emulsions with low or high EO content, stabilized with polysaccharides (PSC) or a combination of PSC-Eudragit® L100-55 (PSC-PLM)…
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Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles…
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral…
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The Match Between Adhesive Mixture Formulation And Device
The LUND University Sweden, Emmercon and the Swedish Foundation for Strategic Research proudly present the following study:
The Match Between Adhesive Mixture Formulation And Device
INTRODUCTION
This study investigates whether it is the formulation or the device that is key to the…
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