Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Downstream Processing of Amorphous Solid Dispersions into Orodispersible Tablets
The formulation development of amorphous solid dispersions (ASDs) towards a patient-friendly oral solid dosage form is proving to be still challenging. To increase patient’s compliance orodispersible tablets (ODTs) can be seen as promising alternative. Two different ASDs were prepared via hot melt…
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The Preparation of Vitamin E Tablets with Fujicalin
See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin® and a comparison with the other commercially available DCPAs.
Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and…
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Exposing Profound Screening Potential of Ethanol-Based Dissolution Media in the Development of…
Characterization of drug release from modified-release products in the presence of alcohol is required to evaluate the possibility of dose dumping due to safety assurance reasons. A generic product containing BCS IV drug and HPMCAS polymer was formulated as amorphous solid dispersion with hot-melt…
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Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet…
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Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets
Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property…
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Fabrication of Sustained-Release Dosages Using Powder-Based Three-Dimensional (3D) Printing…
Three-dimensional (3D)-printed tablets prepared using powder-based printing techniques like selective laser sintering (SLS) typically disintegrate/dissolve and release the drug within a few minutes because of their inherent porous nature and loose structure. The goal of this study was to demonstrate…
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Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation
Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to summarize the pattern of change of tabletability during high shear…
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Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical factors, such as filler (MCC/Mannitol) ratio, mixing time,…
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Clean label ingredients for solid oral dosage forms
In general, clean label is a consumer driven movement, demanding a return to real food and transparency through authenticity. For nutritional supplements, this means that they should contain natural, familiar, simple ingredients that are easy to recognize, understand and pronounce.
Therefore, the…
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Study of different super-disintegrants and their use as a magic ingredient for different…
The time taken by the tablet to break down into fragments or granules is called disintegration. The time it takes for a batch of tablets to dissolve into particles under certain circumstances is called a disintegration test. It essentially entails an aqueous liquid penetrating the tablet, disrupting…
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