Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Excipients in the Paediatric Population: A Review
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric…
Read More...
Read More...
Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit…
The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality. Pharmaceutical drugs often crystallize as needle-shaped (a CMA)…
Read More...
Read More...
Evaluating mechanical properties and tabletability of pharmaceutical powders with a novel…
Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long term.
Tablet is still the most commonly used pharmaceutical…
Read More...
Read More...
Layer by Layer: The Fundamentals of Multi-Layer Tableting
Multi-layer tableting offers a straightforward solution for a variety of challenging formulations. From multi-phasic release systems— to combinations of incompatibles (APIs)—to gastro-retentive tablets, this underutilized method provides efficiency and cost- savings as compared with more…
Read More...
Read More...
Advancing the understanding of the tablet disintegration phenomenon – an update on recent…
Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental quality attribute of immediate release tablets. Although the disintegration phenomenon has been studied for over…
Read More...
Read More...
In-vitro/In-vivo Evaluation of Paclitaxel Freeze-Dried Micellar Nanoparticles Intended for Buccal…
Biopharmaceutics Classified drugs in the category II, III and IV encounter many challenges during development of buccal formulations with adequate bioavailability. This study took the advantage of nanoparticles based on permeability enhancers (PEs) to develop novel paclitaxel (PX) nanoparticles…
Read More...
Read More...
Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP…
Read More...
Read More...
Tablet Excipients – Virtual Video Lessons in Hindi & English by Dr. Tarun Virmani
We provide this virtual lessons by Dr. Tarun Virmani, Associate Professor, MVN University, especially for our Indian Audience.
Drug products usually contain inactive, non-medicinal substances other than the therapeutic agent(s). These substances are called excipients, and they are…
Read More...
Read More...
Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug…
Read More...
Read More...
Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30 mL/h feeding rate, which is about 30x higher than the…
Read More...
Read More...