Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
End-to-End Continuous Manufacturing of Conventional Compressed Tablets: From Flow Synthesis to…
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of acetylsalicylic acid was crystallized continuously in a mixed…
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Solving a sticking related tablet problem by multivariate statistics and computational tomographic…
This work identifies the cause of sticking of granules in an industrial process of tableting. Retrospective multivariate statistical analysis of industrial scale batches' records (PLS, properties and manufacturing conditions of granules and tablets) identified the air flow rate in both granulation…
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The Effect of Inorganic Salt on Disintegration of Tablets with High Loading of Amorphous Solid…
Purpose
While including amorphous solid dispersion (ASD) in tablet formulations is increasingly common, tablets containing high ASD loading are associated with slow disintegration, which presents a challenge to control pill burden for less potent compounds.
Methods
We use a model ASD, composed of…
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The role of excipients and tablet matrix porosity on aspirin stability
Excipient-moisture interaction can be a critical attribute in determination of product stability. This study aimed to investigate influence of integrating excipients having different moisture interaction into moisture sensitive drug formulations. Aspirin was formulated with maize starch (MS),…
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Liquisolid pellets: Mixture experimental design assessment of critical quality attributes…
A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied:…
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Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting
The aim of this study is to investigate the relationship between the structural, molecular, and particulate properties of alginic acid and its functional characteristics in direct compression (tabletability, compressibility, elasticity, deformation mechanism, and disintegration ability).…
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Three-dimensional aspects of formulation excipients in drug discovery: A critical assessment on…
Formulation/pharmaceutical excipients play a major role in formulating drug candidates, with the objectives of ease of administration, targeted delivery and complete availability. Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery. These orphan…
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Problems during tablets manufacturing
Learn more about capping, lamination, picking and sticking as well as mottling, weight and hardness variations in tableting. All brought to to by Dr. Karim Maarif - founder of KMCD
Download the presentation here: some_basic_information_about_punches_tabletting_cycle__1581894721.pdf
Dr. Karim…
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INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by binder attributes. These critical attributes need to be…
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Benefits of Co-processed High-Functionality Excipients in a Continuous Direct Compression Process…
Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling experiments. With these benefits, come challenges as well. In a fully continuous process, the excipients must be added through individual…
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