Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Investigation of powder flowability at low stresses: Influence of particle size and size…
At moderate stresses, shear cells are the preferred method of powder flow measurement. However, several industrial processes operate at low stresses, where the determination of unconfined yield strength by the shear cell technique may be inconsistent, or found not to correlate with observed…
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Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug…
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability. Understanding the biopharmaceutical implications of superdisintegrant variability (changes in material properties), variation (changes in excipient amount) and…
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Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality…
This study aimed to transfer a high shear granulation (HSG) process to a twin-screw granulation (TSG) process while maintaining equivalent dissolution profiles. Ibuprofen (IBP) was used as poorly soluble model drug. Granules were obtained by HSG or TSG according to a full factorial design.
The…
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How to register co-processed excipients – MEGGLE Excipients & Technology
Co-processed Excipients:
Drug approval process | Compendial vs. Novel Excipients
Common Technical Documentation Format – CTD
Throughout a drug approval process a team of drug regulatory experts needs to compile mandatory documentation, which comply with the common technical documentation format.…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs
Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II.…
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Direct Compression of Lactase Tablets with PROSOLV® EASYtab Nutra
The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most suitable tableting process.
The performance of pure lactase…
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Influence of the particle size of copovidone and crospovidone on tablet characteristics
Copovidone and crospovidone are commonly used excipients in solid oral dosage forms for many decades. Typically, copovidone is used as dry binder and crospovidone as disintegrant in tableting formulations. The use of dry binder and disintegrant needs to be balanced to assure both: strong but quickly…
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Formulation of Chlorpheniramine maleate tablets using co-processed excipient as a filller and binder
Co-Processed Excipient (CPE) is technological innovation for tablet preparation through the direct compression method with a quick and straightforward manufacturing process.
This research aimed to formulate and evaluate tablets prepared via a spray drying method with CPE used to improve the…
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Dissolution is beautiful – see the wonders of dissolution with new eyes
Testing of pharmaceutical dosage forms can be beautiful!
SOTAX took a closer look at what happens to tablets and capsules when they disintegrate/dissolve and release their API during dissolution tests - and the results are stunning.
Every day thousands of dissolutions tests are performed in…
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