Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Study of the critical points in combined matrix tablets containing both inert and swelling…
This work estimates for the first time critical points in combined matrices containing varying concentrations of the hydrophilic polymer Hydroxypropyl methylcellulose (HPMC) K100 M CR in presence of a constant percentage of the inert matrix forming polymer Eudragit RS-PO as well as varying…
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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of…
Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints.…
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Ultra–fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive
Orodispersible tablets (ODTs) are a convenient dosage form and a recent trend in formulation development. The fast disintegration is accompanied by rapid removal of the active principle and the excipients from the mouth due to saliva flow and swallowing.
Probiotic bacteria are a promising…
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Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs
Food induced viscosity in the gastrointestinal tract is reported to reduce the bioavailability of tablets containing BCS class 3 drugs, mainly by retarding their disintegration and dissolution of the active pharmaceutical ingredient. The role of formulation factors in minimizing this negative food…
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Effects of Drugs and Excipients on Hydration Status
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal…
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A quick reference to plant gums and mucilages used as a tablet binder
Binders are the ingredients used in tablet granulation process for tablet cohesiveness. This confirms the tablet remains intact after compression. The development of new excipients for potential use as a binding agent in tablet formulations continues to be of interest. Different binding agents are…
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Influence of Immediate Release Tablet Formulation on Dissolution Profile of Paracetamol
Introduction: Paracetamol is analgesic and antipyretic, which is usually in the form of an immediate release tablet formulations. Therapeutic effects in terms of the speed and intensity of the analgesic effect is dependent on speed of liberation from formulation.
Aim: The aim of this work was to…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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