Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
The influence of ethanol on superdisintegrants and on tablets disintegration
Disintegration of immediate release tablets originates from the volume expansion of disintegrants within the formulation. Here, we study the impact of ethanol on the disintegrant expansion and on tablets disintegration. The three most commonly used superdisintegrants, namely sodium starch glycolate…
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Lipids and polymers in pharmaceutical technology: lifelong companions
In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and…
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Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
Continuous powder feeding is a critical step in continuous manufacturing of solid dosage forms, as this unit operation should ensure the mass flow consistency at the desired powder feed rate to guarantee the process throughput and final product consistency. In this study, twin-screw feeding of a…
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Recent trends and future perspective of pharmaceutical wet granulation for better process…
Current trends in pharmaceutical wet granulation have been shifted from traditional approach to systematic and modern approaches, enabling the production of highly engineered product. In this context, quality by design (QbD), modelling, and simulation gradually become important tools in the…
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Evaluating superdisintegrants for their performance in orally disintegrating tablets containing…
Orally disintegrating tablets (ODTs) are gaining importance and popularity due to their numerous advantages. Lysozyme, an enzyme with antibacterial properties, is currently only available as a conventional tablet and syrup. The main aims of this study were to formulate ODTs containing lysozyme using…
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Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy…
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Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating…
The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution assessment of these dosage forms, human saliva should be…
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Pediatric Oral Formulations: An Updated Review of Commercially Available Pediatric Oral Formulations…
Oral pediatric formulations are either ready-to-use or require manipulation, and multi-use or single-use. Strong encouragement for preservative-free pediatric formulations has resulted in fewer multi-use solutions or suspensions in favor of single-use solid oral dosage forms. This updated review…
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Application of natural polymers as pharmaceutical excipients
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used…
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Dropwise Additive Manufacturing of Pharmaceutical Products using Particle Suspensions
The principal method of drug delivery is by oral solid doses, the production of which often necessitates multiple post-crystallization unit operations to ensure content uniformity and/or enhance bioavailability. As an alternative to conventional dose production methods, applications of additive…
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