Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Functional Assessment of Four Types of Disintegrants and their Effect on the Spironolactone Release…
16. February 2017
Abstract
Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as…
Read More...
Read More...
Pharmaceutical applications of native starch in conventional drug delivery : Starch
14. February 2017
Abstract
Starch is a naturally occurring polymer that is present in many green plants. Its nontoxic and nonirritant properties, as well as low cost, ease of modification, and versatility in use have placed starch in a leading position among polymers…
Read More...
Read More...
Formulation and evaluation of Raloxifene hydrochloride tablets with improved dissolution profile
20. January 2017
Abstract
The objective of this research activity was to formulate and evaluate Raloxifene Hydrochloride (RLX HCl) tablets (BCS class II drug) with enhanced aqueous solubility thereby achieving a formulation with improved dissolution characteristics. Tablets were…
Read More...
Read More...
Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion…
15. December 2016
Abstract
Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility…
Read More...
Read More...
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central role in delivering the drug in a safe and effective manner.…
Read More...
Read More...
Functionalised calcium carbonate: a next-generation mineral excipient
11. October 2016
Orally disintegrating tablets (ODTs) are a preferred dosage form compared with conventional tablets because of the numerous advantages they offer, such as rapid dissolution and fast onset of action.
To maintain the porous structure needed for fast dispersion, most…
Read More...
Read More...
Design and Evaluation of Solubility Enhancement of Poorly Soluble Drugs using Liquid Solid Compacts
30. September 2016
ABSTRACT
Oral dosage form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by the oral route. The poor dissolution rate of water insoluble drugs is still a substantial problem…
Read More...
Read More...
Formulation and evaluation of Deflazacort liquisolid tablets
19. May 2016
In the present investigation, liquisolid compact technique is investigated as a tool for enhancement of dissolution of poorly water-soluble drug, Deflazacort. Deflazacort liquisolid tablets were prepared using propylene glycol as non-volatile liquid vehicle,…
Read More...
Read More...
FORMULATION AND IN-VITRO EVALUATION OF LACIDIPINEORAL DISINTEGRATING TABLETS: ENHANCEMENT…
06. May 2016 FORMULATION AND IN-VITRO EVALUATION OF LACIDIPINEORAL DISINTEGRATING TABLETS: ENHANCEMENT OFSOLUBILITY AND DISSOLUTION RATE The aim of present study was to develop the Lacidipine oral disintegrating tablets (LCDP ODTs),…
Read More...
Read More...
Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in…
28. April 2016
Abstract: The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets primarily prepared with hydroxypropyl methylcellulose…
Read More...
Read More...