Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Neusilin Redefining Silica´s Potential in Solid Oral Dosage Forms
Neusilin
WHAT IS IT?
Neusilin® UFL2 is an ultra fine powder of magnesium aluminometasilicate and is widely accepted as a problem solving excipient for oral solid dosage forms.
Make harder tablets and protect it from humidity by adding 0.5-5% Neusilin® UFL2 to a lactose or mannitol…
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The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is…
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Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets
Abstract
Background: Prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age.
Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet.…
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Study of Microcrystalline Cellulose as a Substitute of Magnesium Stearate Towards Functionality of…
Abstract
In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it decreases hardness of tablet in some formulations.…
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Immediate-release dosage form; focus on disintegrants use as a promising excipient
Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms…
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Design, Characterization and Evaluation of Quick Dissolving Matrix BARETab® ODT Tablet In…
Abstract
The oral dissolving tablets is defined as one, which has drug in it and when placed on tongue dissolves completely within a limited span of time, without additional requirement of water. Drug is released, dispersed in the saliva and swallowed and subsequently absorbed in the…
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The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS…
Self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations, designed to improve the solubility of poorly-water soluble drugs. Mesoporous silica is frequently used for SMEDDS solidification by various techniques. One of them is wet granulation, which enables achieving both high…
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Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or…
Abstract
Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the…
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Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil…
The aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to…
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