Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
A technical note: Characterization and evaluation of novel, ready to use coprocessed excipient in…
Abstract
A tablet is composed of different excipients and drug. All excipients have different properties with applications. Excipients are used to provide bulk and help to bind API into a dosage form, excipient should be inert in nature with respectable physical properties. Because the physical…
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A comprehensive understanding of disintegrants and disintegration quantification techniques: From…
Abstract
Disintegration is the process where tablets break down into small particles in a liquid medium. Sufficient disintegration of tablets is conducive to the rapid dissolution of drugs and improve bioavailability, thus it is essential to have a full understanding of the disintegration…
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Omya mineral solutions: Easy formulation with multiple benefits
PRESS RELEASE
Oftringen (Switzerland), September 2023 – Manufacturers in the field of pharma and nutraceuticals can step into a new era of uncomplicated and future-proof formulation: With the Omyanutra® range, Suisse mineral expert Omya offers advanced excipients to overcome the challenge of…
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Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline…
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A tabletability change classification system in supporting the tablet formulation design via the…
In this paper, the material library approach was used to uncover the pattern of tabletability change and related risk for tablet formulation design under the roll compaction and dry granulation (RCDG) process. 31 materials were fully characterized using 18 physical parameters and 9 compression…
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In Vitro and In Vivo Evaluation of Composite Oral Fast Disintegrating Film: An Innovative Strategy…
Here, we evaluate the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat® RS780-based oral fast disintegrating film (ODF). These films were developed by the solvent casting method to minimize the adverse effects of FBP and reduce the…
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Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Abstract
Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing APIs or impurities. The level of nitrites in excipients and…
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VITAMIN C – Tableting with LUBRITAB® RBW Lubricant
Vitamin C (ascorbic acid) is a popular supplement available over the counter in dosage forms such as tablets, capsules, sprinkles and gummies. From a formulator’s perspective, it can be challenging since it is poorly compressible and is very sensitive to moisture. Because of this, it requires…
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Current perspective on the challenges in the development of metformin orally disintegrating tablets…
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent hyperglycaemia with significant morbidity and mortality rates. Currently, metformin is a drug used as first-line therapy during the management of T2DM patients. Despite metformin's effectiveness and potency in…
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Ashland announces Polyplasdone™ Plus multifunctional disintegrant for improved pharmaceutical…
Press Release
Wilmington, Del., June 20, 2023 - Ashland is introducing Polyplasdone™ Plus, a co-processed multifunctional direct compression superdisintegrant containing a glidant and lubricant. Saving time and simplifying development, the multifunctional disintegrant offers superior powder flow…
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