Drug Carrier excipients enhance and interact with the properties of active pharmaceutical ingredients (APIs).
Pharma Excipients
Drug Carrier
Sodium alginate as a pharmaceutical excipient: novel applications of a well-known polymer
Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo…
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Exploring the potential of oleic acid in nanotechnology-mediated dermal drug delivery: An up-to-date…
Oleic acid (OA), the naturally occurring fatty acid, is a multifunctional pharmaceutical excipient with penetration enhancing property for effective skin applications. Topical drug delivery via nano-carriers is also a widely used approach to improve dermal permeation and drug retention.…
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Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against…
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis requires hospitalization due to the severe adverse effects of the drugs, which are administered parenterally.…
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Temperature and pH-responsive nanogels as intelligent drug delivery systems: A comprehensive review
With the advancement of technology and the evolution of modern healthcare systems, the focus is shifting from conventional drug delivery vehicles to novel, nanosized carriers. Nanogels are an example of such nanosized drug delivery systems that have been researched at length. They can be designed to…
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With…
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Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand…
Controlling the time and dose of nanoparticulate drug delivery by administration of small molecule drugs holds promise for efficient and safer therapies. This study describes a versatile approach of exploiting antibody-ligand interactions for the design of small molecule-responsive nanocarrier and…
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Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double…
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside.…
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WITEPSOL® as a carrier of the “Green Rush”
Cannabis was banned almost everywhere on earth for nearly eight decades. But legalisation in many parts of the world triggered a boom in demand. In the meantime, the “green rush” has become a popular term, based on the “gold rush”. Cannabis is known mainly for its intoxicating effects, but it is…
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Engineered-inhaled particles: influence of carbohydrates excipients nature on powder properties and…
Pulmonary drug administration has long been used for local or systemic treatment due to several advantages. Dry powder inhalers emerge as the most promising due to efficiency, ecologic, and drug stability concerns. Coarse lactose-carrier is still the gold standard when inhalation powders are…
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Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon:…
For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissolution apparatus, which does not replicate the…
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