Drug Carrier

This study investigated the ability of hydrophilic electrospun nanofibers to enhance the dissolution rate of poorly soluble drug Meloxicam (MLX). The drug was loaded into polyvinylpyrrolidone (PVP), polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (Soluplus®), sodium lauryl sulfate (SLS)…
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The oral route of administration for lipid-based nanocarriers is of immense importance for the drugs having low bioavailability because of extensive first-pass metabolism. These drug delivery systems have reportedly improved oral bioavailability via lymphatic transport. The solubility issues of a…
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(R)-CE3F4, a specific inhibitor of EPAC1 (exchange protein directly activated by cAMP type 1), has been demonstrated in vitro and in vivo to reduce hypertrophic signaling contributing to heart failure or to control arrhythmia and has shown promise as a drug candidate. However, (R)-CE3F4 exhibits…
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3D printing is a manufacturing technique that is transforming numerous industrial sectors. Within healthcare, it is empowering the small-scale development of personalised medicines that meet the individual needs of patients. 3D printing systems are being currently tested in specialised clinical…
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Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of…
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Intestinal Pseudomonas aeruginosa is highly problematic in immunocompromised patients such as those in intensive care units in hospitals. Phage therapy is an attractive alternative or supplementary therapy to antibiotics as it not only kills multidrug-resistant bacteria, but also minimises the…
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The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery. Well-established formulations like carrier-based blends still show a lack of efficiency. The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide…
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The development of new parenteral biologics with high-vol­ume, high-viscosity formulations (> 1 mL, >15 cP) is triggering the need for devices that can deliver these therapies with the ease, safety, and low injection time required for self-injection.1-3 As these formulations come to market,…
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Silica nanoparticles have entered clinical trials for a variety of biomedical applications, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy. Preliminary results indicate the safety, efficacy and viability of silica nanoparticles under these…
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Objective The aim of this study was to develop a paediatric oral preparation for ibuprofen. Significance Ibuprofen is widely used for defervescence in children, but medication compliance is poor due to its bitter taste. Dry emulsions possess good stability and can be transported and stored…
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