Drug Carrier excipients enhance and interact with the properties of active pharmaceutical ingredients (APIs).
Pharma Excipients
Drug Carrier
Investigation into the role of the polymer in enhancing microwave-induced in situ amorphization
Microwave-induced in situ amorphization is an emerging technology to tackle the persistent stability issue of amorphous solid dispersions (ASDs) during manufacture and storage. The aim of this study was to introduce new effective polymeric carriers with diverse properties to microwave-induced in…
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Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds
Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To…
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Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation…
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles…
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Lipopolysaccharide Nanosystems for the Enhancement of Oral Bioavailability
Nanosystems that incorporate both polymers and lipids have garnered attention as emerging nanotechnology approach for oral drug delivery. These hybrid systems leverage on the combined properties of polymeric and lipid-based nanocarriers while eliminating their inherent limitations. In view of the…
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Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies
In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed a literature review on the studies engaging the usage of…
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Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case…
Fuse deposition modelling (FDM) has emerged as a novel technology for manufacturing 3D printed medicines. However, it is a two-step process requiring the fabrication of filaments using a hot melt extruder with suitable properties prior to printing taking place, which can be a rate-limiting step in…
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Nanocarriers for oral delivery of biologics: small carriers for big payloads
Biologics have gained immense popularity in the past two decades as new and personalized medicines. Yet, the majority of the approved biologics are administered via the parenteral route (i.e., via injections).
Biologics therapy is usually costly as they require administration by a healthcare…
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Recent trends in nanocarrier based approach in the management of dry eye disease
Dry eye disease (DED) represents a major public health issue worldwide. Conventional ophthalmic preparations usually have a short pre-corneal residence time, require frequent and prolonged administration of drugs, lead to poor medication adherence. Nanocarriers because of their unique structural and…
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Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering…
Oral delivery of peptides is a challenge due to their instability and their limited transport and absorption characteristics within the gastrointestinal tract. In this work, we used layering techniques in a fluidized bed dryer to create a configuration in which the active peptide, permeation…
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Sensing technologies and experimental platforms for the characterization of advanced oral drug…
Complex and miniaturized oral drug delivery systems are being developed rapidly for targeted, controlled drug release and improved bioavailability. Standard analytical techniques are widely used to characterize i) drug carrier and active pharmaceutical ingredients before loading into a delivery…
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