Drug Carrier excipients enhance and interact with the properties of active pharmaceutical ingredients (APIs).
Pharma Excipients
Drug Carrier
From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery…
Since the start of the Precision Medicine Initiative by the United States of America in 2015, interest in personalized medicine has grown extensively. In short, personalized medicine is a term that describes medical treatment that is tuned to the individual.
One possible way to realize…
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Resveratrol Loaded Cubic Phase Nanoparticles with Enhanced Oral Bioavailability
Resveratrol (RES), a naturally occurring hydrophobic polyphenolic compound, has shown potential anticancer activity. However, due to low aqueous solubility and extensive first pass metabolism (primarily by cytochrome enzymes), it shows poor oral bioavailability. In the present work, novel RES loaded…
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Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms
The pediatric population suffers from a lack of age-appropriate medicines leading to unsafe situations when off-labelled or unlicensed drugs are used. Assessing the best option to administrate medicines when manipulations are required is essential in order to improve child care. This study aimed to…
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Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil…
Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC-L), in which the presence of lactase acts as the…
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Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can display both these performances concurrently, can enable the…
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Controlled brimonidine release from nanostructured lipid carriers-laden silicone contact lens to…
A novel brimonidine-loaded nanostructured lipid carriers (Br-NLCs)-laden silicone contact lenses were designed for control ocular delivery of brimonidine for effective treatment of glaucoma. The Br-NLCs were found to be spherical in shape with an average size of 100–140 nm and a zeta potential of…
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Development of a furosemide-containing expandable system for gastric retention
More than 50 years ago, the first gastroretentive dosage forms came up. Since then, no practical and at the same time reliable gastroretentive system is available on market. A major obstacle in the development of novel gastroretentive systems is the lack of proper predictive test methods. In the…
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Big family of nano- and microscale drug delivery systems ranging from inorganic materials to…
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver drug to target site have broadly been investigated to upsurge…
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Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
A significant proportion of recently approved drug molecules possess poor aqueous solubility which further restrains their desired bioavailability. Poor aqueous solubility of these drugs poses significant hurdles in development of novel drug delivery systems and achieving target response.…
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Dual Loaded Nanostructured Lipid Carrier of Nano-Selenium and Etravirine as a Potential Anti-HIV…
There is a dire need for dual-long-acting therapy that could simultaneously target different stages of the HIV life cycle and providing a dual-prolonged strategy for improved anti-HIV therapy while reducing oxidative stress associated with the prolonged treatment. Thus, in the present work,…
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