Drug Carrier excipients enhance and interact with the properties of active pharmaceutical ingredients (APIs).
Pharma Excipients
Drug Carrier
Nanomechanical testing in drug delivery: theory, applications, and emerging trends
Mechanical properties play a central role in drug formulation development and manufacturing. Traditional characterization of mechanical properties of pharmaceutical solids relied mainly on large compacts, instead of individual particles. Modern nanomechanical testing instruments enable…
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Intranasal delivery of insulin by self-emulsified nanoemulsion system: In vitro and in vivo studies
The main objective of this research was to develop a self-emulsified nanoemulsion (SEN) dosage form of insulin where insulin is loaded into the lipid phase of the nanoemulsion for enhanced absorption through intranasal delivery. When loaded into the lipid droplets (oil phase), insulin can be…
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A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory…
Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and…
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Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS, and two stabilizers (PVP and PVA) were evaluated for NPs…
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Printing Drugs onto Nails for Effective Treatment of Onychomycosis
Inkjet printing (IJP) is an emerging technology for the precision dosing of medicines. We report, for the first time, the printing of the antifungal drug terbinafine hydrochloride directly onto nails for the treatment of onychomycosis. A commercial cosmetic nail printer was modified by removing the…
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Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
For the past several years, dementia, is one of the predominantly observed groups of symptoms in a geriatric population. Alzheimer’s disease (AD) is a progressive memory related neurodegenerative disease, for which the current Food and drug administration approved therapeutics are only meant for a…
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Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In…
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics (F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations (F10 and F11) had their particle size in the nano range with…
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Pulmonary vaccine delivery: An emerging strategy for vaccination and immunotherapy
Vaccination has been known as the most successful health strategy for the prevention of infectious diseases, and their subsequent disability conditions. Conventional vaccination is based on parenteral administration and therefore requires needles, cold-chain storage and distribution. To meet these…
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A single oral dose of celecoxib-loaded solid lipid nanoparticles for treatment of different…
Schistosomiasis, a neglected tropical parasitic disease, is associated with severe pathology, mortality and economic loss. The treatment and control of schistosomiasis depends mainly on a single dose of praziquantel (PZQ). Drug repurposing and nanomedicine attract great attention to improve…
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Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks…
Polymeric micelles (PMs) have been explored pre-clinically for the delivery of chemotherapeutics to treat cancer. Their unique features, such as easy surface functionalization, stimuli-responsiveness, good stability, ability to modify drug release, enhanced permeation and retention effect, and…
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