Drug Carrier excipients enhance and interact with the properties of active pharmaceutical ingredients (APIs).
Pharma Excipients
Drug Carrier
Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC…
The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective…
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Experimental Design and Optimization of a Novel Dual-release Drug Delivery System With Therapeutic…
The objective of this study was to develop clarithromycin-loaded lipid nanocarriers and incorporate them into microcapsules for pH-specific localized release of clarithromycin in the Helicobacter pylori microenvironment in order to obtain a gastro-retentive and pH-sensitive formulation. A…
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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using…
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary amorphous solid dispersions (SDs) of Coenzyme Q10 (CoQ10), a biopharmaceutics classification system (BCS) II compound and Soluplus® were prepared to…
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Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal…
Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral…
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Is Oral Lipid-Based Delivery for Drug Targeting to the Brain Feasible?
This review outlines the feasibility of oral lipid-based targeted delivery of drugs to the brain, including permeation of the central nervous system’s (CNS) protective blood-brain barrier (BBB). The structure of the BBB and disruption caused by varying disease states highlights the need for…
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Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics
The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2 infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of candidates was evaluated, with mRNA-based vaccines emerging as leaders due to how quickly they were available for emergency use…
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A review on recent advances in nanomedicines for the treatment of pulmonary tuberculosis
Tuberculosis (TB) has been the most life-threatening contagious disease caused by pathogenic mycobacterium tuberculosis. The World Health Organization (WHO) report, 2020 estimated that this highly burden bacterial infection becomes the prime root for the death of 1.4 million people worldwide. There…
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Nanostructured Lipid Carrier: A Potential System for Enhanced Oral Bioavailability of Felodipine
Background: Felodipine is BCS class II drug with poor and variable bioavailability due to its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the study Nanostructured lipid carriers (NLCs) of Felodipine were formulated to improve its solubility and bioavailability.…
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Self-emulsification in chemical and pharmaceutical technologies
The interest in the low energy self-emulsification techniques has exploded in the recent years, driven by three main trends: by the transition to “greener” technologies in both its aspects – less energy consumption and replacement of the petrochemicals by natural ingredients; by the costly and…
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Dose-independent Drug Release from 3D Printed Oral Medicines for Patient-specific Dosing to Improve…
Fused deposition modelling (FDM) 3D printing provides the ability to address individual patients’ therapeutic needs without having to change the formulation every time. This is particularly interesting for dosing and release modelling. In this study, a geometry model was developed that can represent…
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