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Drug Delivery
Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient…
Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies are available to select a suitable approach and guide…
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Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic…
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Proposing a model study, this research shows how most…
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PLA-PCL Microsphere Formulation to Deter Abuse of Prescription Opioids by Smoking
Opioids are commonly prescribed across the US for pain relief, despite their highly addictive nature that often leads to abuse and overdose deaths. Abuse deterrent formulations (ADFs) for prescription opioids make the non-therapeutic use of these drugs more difficult and less satisfying. Although…
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In Vitro Release, Mucosal Permeation and Deposition of Cannabidiol from Liquisolid Systems: The…
This work investigated the influence of liquid vehicles on the release, mucosal permeation and deposition of cannabidiol (CBD) from liquisolid systems. Various vehicles, including EtOH, nonvolatile low- and semi-polar solvents, and liquid surfactants, were investigated. The CBD solution was…
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3D printing for the development of implantable devices for cardiovascular disease treatment
Additive manufacturing (also known as 3D printing) has proven to be an effective technology for pharmaceutical and biomedical applications . Additive manufacturing is a family of technologies used to prepare 3D objects by adding layers of material in a sequential way . Typically, 3D-printing…
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Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with low solubility convey a higher risk of…
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Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products
Although medicinal natural products and their derivatives have shown promising effects in disease therapies, they usually suffer the drawbacks in low solubility and stability in the physiological environment, low delivery efficiency, side effects due to multi-targeting, and low site-specific…
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Innovation in Paediatric Drug Delivery with miniMist®
What is miniMist®?
miniMist® is an inhalation device for children that makes inhalation of pharmaceuticals easy and highly effective using gold standard methods.
miniMist® uses break-through technology and delivers treatments in a way they have never been done before.
miniMist® can be…
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Chitosan Based MicroRNA Nanocarriers
Vectorization of microRNAs has shown to be a smart approach for their potential delivery to treat many diseases (i.e., cancer, osteopathy, vascular, and infectious diseases). However, there are barriers to genetic in vivo delivery regarding stability, targeting, specificity, and internalization.…
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A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
Since the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers for RNA packaging and delivery. Nevertheless, the…
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