Drug Delivery

Floating drug delivery is a gastro-retentive delivery system offering an advantage for poor-bioavailability drugs, which have low absorption in the upper gastrointestinal tract. This system can be administered effectively, increasing bioavailability and optimizing absorption. This technique can also…
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Background: The goal of this research was to design and characterize quercetin microemulsions (MEs) to resolve water solubility issues related to quercetin and improve transcorneal permeation into the eye. Methods: MEs were prepared by the phase diagram method. Oily phase (oleic…
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Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally…
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The main focus of this study is the preparation of lignin-based spherical particles as drug delivery systems. First, particles were prepared with the use of kraft lignin and the cationic surfactant hexadecyl (trimethyl)ammonium bromide (CTAB), and their physicochemical and structural characteristics…
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Dry Powder Inhalers (DPI) and Lactose Using a dry powder inhaler (DPI) for drug delivery can provide many advantages over traditional oral delivery of pharmaceuticals. DPI’s also offer advantages over older respiratory delivery methods such as those using nebulizers or pressurized CFC containing…
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COVID-19 is marked by extensive damage to the respiratory system, often accompanied by systemic manifestations, due to both viral cytopathic effects and hyperinflammatory syndrome. Therefore, the development of new therapeutic strategies or drug repurposing aiming to control virus replication and…
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See in the following the overview on the usage fields of polyamino acids and the service spectrum of PMC Isochem as CDMO in this area: Why PolyAmino Acids - PAA Functional Excipients Biodegradable Polymers Drug Delivery & Drug Conjugate Alternative to PEG (i.e. polysarcosine)…
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Osteoarthritis (OA) is a prevalent degenerative disease that has a significant impact on patients' lives. Celecoxib (CXB) is now primarily used to treat OA with oral dosing. CXB's limited water solubility, on the other hand, restricts its therapeutic application. We developed a delivery system of…
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Self-emulsifying drug delivery systems (SEDDS) are a promising strategy to improve the oral bioavailability of poorly water-soluble drugs (PWSD). The excipients of SEDDS enable permeation through the mucus and gastro-intestinal barrier, inhibiting efflux transporters (e.g. P-glycoprotein) of drugs.…
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Purpose: While developing huperzine A (HupA) to explore new approaches to treating Alzheimer’s disease (AD), intranasal administration was proposed as an alternative route to deliver drugs into the brain. This study aimed to prepare nanoemulsions (NEs) of HupA to investigate their potential…
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