Drug Delivery

Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense porous network that coats all the exposed epithelia not covered with the skin. The layer provides protection to the underlying gastrointestinal, respiratory, and female reproductive tracts, in addition to the…
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MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac® General information The delivery of active pharmaceutical ingredients (APIs) via the lung is becoming increasingly important as ever more patients all over the world suffer from chronic respiratory…
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For lipid-based excipients and active pharmaceutical ingredients “Made in Germany” – you can rely on IOI Oleo. Decades of experience and expertise shape today’s quality of our specialty products and drive new product developments and operational excellence. As a result, IOI Oleo brand names are…
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The objective of study was to formulate and optimize poly lactic-co-glycolic acid based long-acting injectable microspheres of Paliperidone palmitate (PP) using Box- Behnken design for treatment of schizophrenia. The oral bioavailability of PP is 28%, it necessitates the formulation of PP in…
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The purpose of this study was to develop astaxanthin (AST)-loaded self-microemulsifying drug delivery system (SMEDDS) tablets and evaluate their physicochemical and biological properties. The optimized liquid (L)-AST SMEDDS formulation was composed of rice bran oil (33.67%), Kolliphor® RH 40…
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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on…
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Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward…
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YOUR FORMULATION CHALLENGE - IOI Oleo SOLUTIONS According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or permeabilities, and the majority of drug candidates have…
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Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible adverse effects, starting with a general cytotoxicity screening. The Horizon…
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Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the…
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