Browsing Category
Drug Delivery
A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose
Objective
To examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal liquid spray.
Methods
FMXIN001, was developed by blending drug microspheres with larger lactose monohydrate particles, that serve as diluent and…
Read More...
Read More...
Development and Dissolution Study of a β-Galactosidase Containing Drinking Straw
Today, in addition to many different physicochemical and pharmacological properties of the active ingredients and excipients, the developer of a pharmaceutical formulation must take into account several factors during the formulation process in order for the patient to cooperate to use the…
Read More...
Read More...
Smart Hydrogels for Advanced Drug Delivery Systems
Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great…
Read More...
Read More...
Can pulmonary RNA delivery improve our pandemic preparedness?
The coronavirus pandemic has changed our perception of RNA medicines, and RNA vaccines have revolutionized our pandemic preparedness. But are we indeed prepared for the next variant or the next emerging virus? How can we prepare? And what does the role of inhaled antiviral RNA play in this regard?…
Read More...
Read More...
Starch hydrogels as targeted colonic drug delivery vehicles
Targeted colonic drug delivery systems are needed for the treatment of endemic colorectal pathologies, such as Crohn's disease, ulcerative colitis, and colorectal cancer. These drug delivery vehicles are difficult to formulate, as they need to remain structurally intact whilst navigating a wide…
Read More...
Read More...
Comparative study on the real-time monitoring of a fluid bed drying process of extruded granules…
The process of fluidized bed drying of granules was comparatively evaluated by on-line real-time measurements of granule moisture content (MC) using near-infrared spectroscopy (NIR) and audible acoustic emission (AAE). The extruded granules were prepared by kneading a powder blend containing…
Read More...
Read More...
Intranasal lipid nanocarriers: Uptake studies with fluorescently labeled formulations
Drug delivery by the intranasal route allows both systemic absorption and non-invasive brain targeting, due to the unique connection provided by the olfactory and trigeminal nerves between the brain and the external environment. Lipid nanocarriers can improve intranasal drug delivery by enhancing…
Read More...
Read More...
Dispensing of minitablets – Has the problem been resolved?
Recently, minitablets have been given extensive coverage in literature, as they are perfectly matched to the current therapy individualization trend. Within this scope, special attention is paid to minitablets that enable convenient drug intake for patients with swallowing problem. However, the…
Read More...
Read More...
Assessment of pharmaceutical powders flowability and comparative evaluation of lubricants on…
Lubricants have a small appearance but act as a giant frame in flow behavior during dosage form preparation. In the present study, different lubricants were evaluated and compared. Both traditional and advanced techniques were used to evaluate raw materials and prepared granules flow properties. The…
Read More...
Read More...
Pain management with transdermal drug administration: A review
Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug retention time.
The transdermal route, a…
Read More...
Read More...