Drug Delivery

Nanomedicine plays a vital role in targeting therapeutics to the desired site of action. Over the years, several nanomedicines, like monoclonal antibodies (Rituximab, Brentuximab Vedotin, Alemtuzumab, etc.), nanostructured lipid carriers, conjugated polymeric nanoparticles, solid lipid…
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The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and…
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Objective To perform a bibliometric analysis in the field of ocular drug delivery research to characterize the current international trends and to present visual representations of the past and emerging trends on ocular drug delivery research over the past decade. Highlights 4334…
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Hollow mesoporous organosilica nanoparticles (HMOSNPs) have provided unique opportunities to improve therapeutic efficacy of the encapsulated drugs due to versatile hybrid frameworks and tunable pore sizes, biodegradable nature and intelligent performance. Highlights The efficacy of…
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Nanocapsules (NCs) are drug delivery nanosystems that contain an oily core, stabilized by a surfactant, and surrounded by a polymeric shell. The assembling of the components is based on physical and physicochemical forces, and, hence, usually, only a fraction of each component is finally part of the…
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Due to the high surface area, adjustable surface and pore structures, and excellent biocompatibility, nano- and micro-sized silica have certainly attracted the attention of many researchers in the medical fields. This review focuses on the multifunctional roles of silica in different pharmaceutical…
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In the last few decades, the interest in biodegradable materials for biomedical applications has increased significantly. Both natural and synthetic biodegradable polymers (BDPs) have been broadly explored for various biomedical applications. These include sutures and wound dressings, screws for…
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In the current research, a thymoquinone-enriched naringenin (NGN)-loaded nanostructured lipid carrier (NLC) was developed and delivered via the nasal route for depression. Thymoquinone (TQ) oil was used as the liquid lipid and provided synergistic effects. A TQ- and NGN-enriched NLC was developed…
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Metformin hydrochloride (MTH) has been associated with poor/incomplete absorption (50–60%), low bioavailability, short half-life (0.4–0.5 h), high dosage and dose-related side effects. To overcome these barriers and improve oral bioavailability and efficacy of MTH, surface-modified nanostructured…
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Aim Evaluation of different polyhydroxy surfaces in SEDDS to overcome the limitations associated with conventional polyethylene glycol (PEG)-based SEDDS surfaces for intracellular drug delivery. Highlights Polyethylene glycol- (PEG-) surfactants in self-emulsifying drug delivery…
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