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Drug Delivery
Switching from batch to continuous granulation: A Case Study of metoprolol succinate ER tablets
Continuous manufacturing (CM) has been used to produce several immediate release drug products. No extended-release (ER) product manufactured employing CM technology has been approved yet. This study investigated the critical aspects of switching from the batch mode of high shear granulation to the…
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3D printed drug-loaded implantable devices for intraoperative treatment of cancer
Surgery is an important treatment for cancer; however, local recurrence following macroscopically-complete resection is common and a significant cause of morbidity and mortality. Systemic chemotherapy is often employed as an adjuvant therapy to prevent recurrence of residual disease, but has limited…
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Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as…
Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation of solid oral dosage forms requires the drying of PECs, which may affect their physicochemical and biopharmaceutical…
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Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular…
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the design, development, and physicochemical characterization of lactoferrin-loaded…
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Nanomechanical testing in drug delivery: theory, applications, and emerging trends
Mechanical properties play a central role in drug formulation development and manufacturing. Traditional characterization of mechanical properties of pharmaceutical solids relied mainly on large compacts, instead of individual particles. Modern nanomechanical testing instruments enable…
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Intranasal delivery of insulin by self-emulsified nanoemulsion system: In vitro and in vivo studies
The main objective of this research was to develop a self-emulsified nanoemulsion (SEN) dosage form of insulin where insulin is loaded into the lipid phase of the nanoemulsion for enhanced absorption through intranasal delivery. When loaded into the lipid droplets (oil phase), insulin can be…
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A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory…
Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and…
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Advances in controlled drug delivery to the sinonasal mucosa
Controlled drug delivery is a valuable strategy for increasing local therapeutic concentrations in a sustained manner, particularly in locations that are difficult to access. One such target is the sinonasal mucosa, which can be chronically inflamed in patients with rhinitis or rhinosinusitis…
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Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS, and two stabilizers (PVP and PVA) were evaluated for NPs…
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Enhancing Stability and Mucoadhesive Properties of Chitosan Nanoparticles by Surface Modification…
Background: The present study aimed to fabricate surface-modified chitosan nanoparticles with two mucoadhesive polymers (sodium alginate and polyethylene glycol) to optimize their protein encapsulation efficiency, improve their mucoadhesion properties, and increase their stability in biological…
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