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Drug Delivery
Formulating for the Future: Oral Drug Delivery for Improving Bioavailability & Patient Outcomes
Oral drug administration is critical for the delivery of drugs in various therapeutic areas, such as cardiovascular and pain management. It is considered the preferred route of administration due to its significant advantages, including being both painless and convenient. The importance of oral drug…
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Self-emulsification in chemical and pharmaceutical technologies
The interest in the low energy self-emulsification techniques has exploded in the recent years, driven by three main trends: by the transition to “greener” technologies in both its aspects – less energy consumption and replacement of the petrochemicals by natural ingredients; by the costly and…
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Dose-independent Drug Release from 3D Printed Oral Medicines for Patient-specific Dosing to Improve…
Fused deposition modelling (FDM) 3D printing provides the ability to address individual patients’ therapeutic needs without having to change the formulation every time. This is particularly interesting for dosing and release modelling. In this study, a geometry model was developed that can represent…
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FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to investigate the influence of shape and infill percentage on…
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QbD Approach towards Robust Design Space for Flutamide/Piperine Self-Emulsifying Drug Delivery…
Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim of this study was to develop a flutamide/piperineco-loaded self-emulsifying drug delivery system (FPSEDDS) to inhibit flutamide-induced liver injury by utilizing piperine as…
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Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
The use of chemotherapeutic agents such as docetaxel (DTX) in anticancer therapy is often correlated to side effects and the occurrence of drug resistance, which substantially impair the efficacy of the drug. Here, we demonstrate that self-emulsifying drug delivery systems (SEDDS) coated with…
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Eudragit coated microemulsion for enhanced efficacy of spiramycin against toxoplasmic encephalitis
The study investigated Eudragit coated microemulsion (ME) for oral delivery of spiramycin in treatment of toxoplasmic encephalitis. The goal was to augment the efficacy of ME by protection from gastrointestinal conditions and/or providing bioadhesion. Uncoated and coated MEs comprise labrafil as…
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ROQUETTE’S LYCAGEL® OFFERING JUST GOT BIGGER
Roquette’s NEW premix solution for veggie softgel formulation is here – a ready-to-use, plant-based blend for nutraceutical AND pharmaceutical softgel formulations. LYCAGEL® Premix is easily incorporated into existing manufacturing processes and can help you bring your products to market faster –…
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PCL-PEG copolymer based injectable thermosensitive hydrogels
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ …
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Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release…
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in…
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