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Drug Delivery
Drug delivery to the intestinal lymph by oral formulations
Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The intestinal lymph harbors numerous lymphocyte subsets, and DDS containing lipids such as triglycerides and fatty acids can deliver drugs to the lymph…
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Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for…
“On demand” hormonal female-controlled pericoital contraception is one strategy which could be used to minimize the impact of unintended pregnancy. Nestorone (NES) is a potent contraceptive, with relatively few side effects in comparison with other contraceptives. NES presents an attractive option…
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Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid…
A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium…
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Formulate you liquid dose applications with excipients from Merck
Benefit from a comprehensive product portfolio and exceptional service in liquid formulation.
Immediately ready and easy to administer, liquid dosage forms are an essential part of any pharmaceutical portfolio. In order to help you stand out from the competition, we provide you with an extensive…
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Experience the future of Titanium Dioxide replacement: VIVACOAT® free
Discover bright white films and brilliant colors at reasonable weight gains even on your darkest tablet cores!
Enjoy the freedom of choice when banning TiO2 from your tablet coatings:
TiO2- freeTalcum-free Free choice of colors
Low weight gainHigh solid contentNo limits for dark tablet…
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Physico-chemical analysis of electrospun fibers – A systematic approach
Electrospun fibers emerged as promising drug delivery systems for various pharmaceutical applications due to their favorable properties. However, while for established drug delivery systems (e.g. tablets or capsules) standardized analytical procedures exist, the methodologies for characterization of…
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Nanostructured Lipid Carriers Loaded with Lippia sidoides Essential Oil as a Strategy to Combat the…
The emerging pathogen Candida auris is an emerging fungal pathogen that was associated with nosocomial infectious outbreaks. Its worldwide incidence and the emerging multidrug-resistant strains highlight the urgency for novel and effective antifungal treatment strategies. Lippia sidoides essential…
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Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory…
The in vivo ability of thermosensitive nanogel containing ibuprofen for bioadhesion on the surface of teeth submitted to bleaching and drug delivery through dentinal tubules to the dental pulp are evaluated in Wistar rats. Drug-loaded self-assembled oil in water nanoemulsions present droplet size…
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Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-dependent anatomical and physiological changes in…
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Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic…
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in…
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