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Drug Delivery
Gum-based nanocapsules comprising naphthoquinones enhance the apoptotic and trypanocidal activity…
Nanoencapsulation is a promising approach to enhance the therapeutic potential of a drug. Herein, three selected naphthoquinone (NTQ) derivatives, based on the IC50 value against Trypanosoma evansi, were encapsulated using gum damar as biocompatible and biodegradable natural gum via…
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Novel Bilayer Microarray Patch-Assisted Long-Acting Micro-Depot Cabotegravir Intradermal Delivery…
Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited,…
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Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable…
In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems.
This review focuses on spray congealing and…
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Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for…
A bioequivalence study comparing two fixed dose combination tablets containing 200 mg ibuprofen and 30 mg pseudoephedrine hydrochloride showed bioequivalence for pseudoephedrine AUC and Cmax, but the reference product showed higher Cmax than the test product in fasted conditions. The main difference…
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Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial…
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Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1…
GSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1, with a 2–3 h half-life. This study evaluated if a once-daily modified-release formulation of GSK2982772 could be developed with no significant food effect.
Methods
Part A evaluated the pharmacokinetics of GSK2982772…
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Development and evaluation of nano-formulations for immediate release oral dosage forms of poorly…
Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Zun Huang
Solubility and dissolution rate are essential for the oral absorption and thus bioavailability of…
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Lipid-based nanocarriers for oral delivery of peptides
Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border. We have evaluated the capacity of solid lipid…
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Electrospun poly(ω-pentadecalactone-co-ε-caprolactone)/gelatin/chitosan ternary nanofibers with…
In recent years, there is an increasing attention on biocompatible electrospun nanofibers for drug delivery applications since they provide high surface area, controlled and sustained drug release, and they mimic the extracellular matrix. In the present study, tetracycline hydrochloride (TCH)…
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Lipid Nanoparticles for the Posterior Eye Segment
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior…
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