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Drug Delivery
Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review
Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment…
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Solvent-Free Fabrication of Biphasic Lipid-Based Microparticles with Tunable Structure
Lipid-based biphasic microparticles are generally produced by long and complex techniques based on double emulsions. In this study, spray congealing was used as a solvent-free fabrication method with improved processability to transform water-in-oil non-aqueous emulsions into spherical solid…
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Exploring the potential of oleic acid in nanotechnology-mediated dermal drug delivery: An up-to-date…
Oleic acid (OA), the naturally occurring fatty acid, is a multifunctional pharmaceutical excipient with penetration enhancing property for effective skin applications. Topical drug delivery via nano-carriers is also a widely used approach to improve dermal permeation and drug retention.…
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Fabrication Methods and Form Factors of Gellan Gum-Based Materials for Drug Delivery and Anti-Cancer…
Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main challenges of cancer treatment. Exploration of drug delivery methods is a growing field of research, which involves a variety of materials and processing techniques. A natural polymer, gellan gum…
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Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered…
Despite much progress in regulations to improve paediatric drug development, there remains a significant need to develop better medications for children. For the design of oral dosage forms, a detailed understanding of the specific gastrointestinal (GI) conditions in children of different age…
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Orodispersible Films: A Delivery Platform for Solid Lipid Nanoparticles?
To overcome the poor bioavailability observed for many newly developed active pharmaceutical ingredients (APIs), an appropriate formulation strategy is necessary. One approach is the formulation of these substances in solid lipid nanoparticles and their further processing into solid dosage forms. A…
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Temperature and pH-responsive nanogels as intelligent drug delivery systems: A comprehensive review
With the advancement of technology and the evolution of modern healthcare systems, the focus is shifting from conventional drug delivery vehicles to novel, nanosized carriers. Nanogels are an example of such nanosized drug delivery systems that have been researched at length. They can be designed to…
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Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of…
High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing parameters, compression of granules and evaluation…
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Pectin microparticles for peptide delivery: optimization of spray drying processing
Spray-dried pectin microparticles can potentially improve the oral bioavailability of peptides by virtue of their mucoadhesion. However, developing such formulations with desirable quality attributes is challenging due to the sensitivity of microparticle critical quality attributes towards changes…
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Fabrication of three-dimensional-printed ofloxacin gastric floating sustained-release tablets with…
The objective of this study was to develop a novel ofloxacin gastric floating system with different internal structures by paste extrusion printing and to explore the relationship between tablets with different structures and the release behavior and floating time. The gastric floating sustained…
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