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Drug Delivery
Controlled and Local Delivery of Antibiotics by 3D Core/Shell Printed Hydrogel Scaffolds to Treat…
Soft tissue infections in open fractures or burns are major cause for high morbidity in trauma patients. Sustained, long-term and localized delivery of antimicrobial agents is needed for early eradication of these infections. Traditional (topical or systemic) antibiotic delivery methods are…
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With…
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Microfluidic-Generated Immunomodulatory Nanoparticles and Formulation-Dependent Effects on…
Nanoparticles (NPs) have emerged as a highly useful and clinically translatable drug delivery platform for vast therapeutic payloads. Through the precise tuning of their physicochemical properties, NPs can be engineered to exhibit controlled drug release properties, enhanced circulation times,…
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Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand…
Controlling the time and dose of nanoparticulate drug delivery by administration of small molecule drugs holds promise for efficient and safer therapies. This study describes a versatile approach of exploiting antibody-ligand interactions for the design of small molecule-responsive nanocarrier and…
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Clinical translation of advanced colonic drug delivery technologies
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are…
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3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of…
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Zein as a versatile biopolymer: different shapes for different biomedical applications
In recent years, the interest regarding the use of proteins as renewable resources has deeply intensified. The strongest impact of these biomaterials is clear in the field of smart medicines and biomedical engineering. Zein, a vegetal protein extracted from corn, is a suitable biomaterial for all…
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Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double…
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside.…
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WITEPSOL® as a carrier of the “Green Rush”
Cannabis was banned almost everywhere on earth for nearly eight decades. But legalisation in many parts of the world triggered a boom in demand. In the meantime, the “green rush” has become a popular term, based on the “gold rush”. Cannabis is known mainly for its intoxicating effects, but it is…
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Hyaluronic Acid Nanogel as a Protein Delivery System
Purpose
Hyaluronic acid (HA) nanogel has hyaluronic acid in the main chain, a hydrophilic, biocompatible material with low toxicity, and a hydrophobic group in the side chain. A nanoordered gel is spontaneously formed, due to its hydrophilic-hydrophobic interactions, in which it is possible to load…
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