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Drug Delivery
An Investigation of a Novel, Directly Compressible, Oil-carrying Excipient in a Solid,…
JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the third poster:
Introduction
Currently in the small-molecule therapeutic arsenal around40%oftheactivepharmaceuticalingredients (APIs) are poorly water-soluble with up to 90 % of the APIs in current development…
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Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of…
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying. Comprehensive evaluations comprised particle size, %entrapment…
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Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic screening of excipients was conducted to determine the most…
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Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on…
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Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum…
Mesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential.…
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Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of…
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of…
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Evonik makes five generations healthier with EUDRAGIT® coatings for targeted drug delivery
PRESS RELEASE
Evonik Health Care Essen, Germany, March 14, 2024
EUDRAGIT® polymers have been used as coatings to create more effective drugs for 70 years. Over the decades, the portfolio of methacrylate polymers has established itself as the industry standard with more than 23,000…
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Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood…
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral formulations. Therefore, it is necessary to understand the effects of excipients on the behavior of SEDDS formulations upon parenteral administration, particularly…
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Chrono-tailored drug delivery systems: recent advances and future directions
Abstract
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle,…
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Current State of Minitablet Product Design: A Review
Abstract
Interest in minitablets (MTs) has grown exponentially over the last 20 years and especially the last decade, as evidenced by the number of publications cited in Scopus and PubMed. MTs offer significant opportunities for personalized medicine, dose titration and flexible dosing, taste…
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