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Drug Delivery
Optimization study of combined enteric and time-dependent polymethacrylates as a coating for colon…
Formulation design for colon-specific delivery of 5-aminosalicylic acid (5-ASA) could bring some therapeutic benefits in the treatment of ulcerative colitis (UC).
In the current study, a 32 full factorial design was used to predict optimum coating composed of two enteric (poly methacrylic acid,…
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Oral insulin delivery by epithelium microenvironment-adaptive nanoparticles
Oral protein drug delivery using nano-based systems remains challenging, as contradictory surface properties are required for efficient navigation through the intestinal mucus and epithelium barriers. Therefore, new nanoplatforms with tunable surface properties in vivo are urgently needed. Inspired…
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Omyanutra® 300 Flash – The all-in-one solution for ODTs and FDTs
The world of nutraceutical tablet formulation is complex and many critical values have to be considered during development - like dissolution properties, shelf-life stability, or exposure to environmental challenges (oxygen, light, humidity and high or low temperatures).
The high number of…
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Injectable Liposome Based Supramolecular Hydrogels for the Programmable Release of Multiple Protein…
Directing and manipulating biological functions is at the heart of next-generation biomedical initiatives such as tissue and immuno-engineering. Yet, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times…
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Development of pH-Sensitive Chitosan-g-poly(acrylamide-co-acrylic acid) Hydrogel for Controlled Drug…
The present study aimed to develop a pH-sensitive chitosan-based hydrogel for controlled delivery of an anti-hepatitis B drug, tenofovir disoproxil fumarate (TDF). Free radical polymerization was utilized to graft acrylamide and acrylic acid using N,N-methylene bisacrylamide as the crosslinker.…
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Development and in-vitro in-vivo characterization of in-situ gelling sustained-release nevirapine…
Nevirapine is a BCS class-II drug used in the treatment and prevention of HIV/AIDS, specifically HIV-1. This study was aimed to develop and evaluate a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension (SRNPS) for treatment and prevention of mother-to-child…
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Emulgel Approach to Formulation Development: A Review
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The…
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Development and Pharmacokinetic Evaluation of a Self-Nanoemulsifying Drug Delivery System for the…
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be limited without adequate formulation strategies.…
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Towards next-generation personalization of tacrolimus treatment: a review on advanced diagnostic and…
The benefit of personalized medicine is that it allows the customization of drug therapy – maximizing efficacy while avoiding side effects. Genetic polymorphisms are one of the major contributors to interindividual variability. Currently, the only gold standard for applying personalized medicine is…
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In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for periodontal pocket drug…
Periodontitis is a chronic inflammatory disease of gum resulting from Porphyromonas gingivalis infectious at periodontal pockets. In situ forming gel (ISG) effectively delivers the antimicrobial agents to this targeted site. This study was to develop the dimethyl sulfoxide (DMSO) removal-based ISGs…
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