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Drug Delivery
Smartphone-enabled 3D printing of medicines
3D printing is a manufacturing technique that is transforming numerous industrial sectors. Within healthcare, it is empowering the small-scale development of personalised medicines that meet the individual needs of patients. 3D printing systems are being currently tested in specialised clinical…
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Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing
Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of…
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Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral…
Various physiological factors in the gastrointestinal (GI) tract affect the in vivo performance of orally administered dosage forms. In this review article, we summarize the formulation-related interspecies differences (particularly under the fasted state) between humans and laboratory animals.…
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Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections
Intestinal Pseudomonas aeruginosa is highly problematic in immunocompromised patients such as those in intensive care units in hospitals. Phage therapy is an attractive alternative or supplementary therapy to antibiotics as it not only kills multidrug-resistant bacteria, but also minimises the…
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Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using…
Purpose: This study aimed to formulate an orally disintegrating tablet (ODT) containing both baclofen and meloxicam together for treating osteoarthritis.
Methods: Direct compression method was used to prepare ODTs using three types of co-processed excipients (Prosolv ODT G2®, F-melt®, and…
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Surface energy considerations in ternary powder blends for inhalation
The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery. Well-established formulations like carrier-based blends still show a lack of efficiency. The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide…
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Supramolecular Organization of Polymer Prodrug Nanoparticles Revealed by Coarse-Grained Simulations
Drug–polymer conjugates that can self-assemble into nanoparticles are promising drug delivery systems that improve the drug bioavailability and allow their controlled release. However, despite the possibility of reaching high drug loadings, the efficiency of the drug release, mediated by cleavage of…
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DEVICE DEVELOPMENT – Selecting Drug Delivery Systems for Higher Doses, Higher Viscosities &…
The development of new parenteral biologics with high-volume, high-viscosity formulations (> 1 mL, >15 cP) is triggering the need for devices that can deliver these therapies with the ease, safety, and low injection time required for self-injection.1-3 As these formulations come to market,…
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Clinical translation of silica nanoparticles
Silica nanoparticles have entered clinical trials for a variety of biomedical applications, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy. Preliminary results indicate the safety, efficacy and viability of silica nanoparticles under these…
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Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram, isopropyl palmitate (IPP) was chosen as the oil phase. Meanwhile,…
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