Drug Delivery

Abstract The administration of medications to children has been a challenge for parents and caregivers for generations. Pharmaceutical companies have often overcome the difficulties of weight-based dosing and the ­inability of most young children to swallow solid dosage forms by creating oral…
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Polymeric excipients ensure the site-specific delivery of the drug at the desired rate for a specified duration to achieve better efficacy. Pharmaceutical excipients were supposed to be pharmacologically inert, and must assure a controlled rate of delivery, an adjustable pharmacokinetic and…
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Abstract The electrospray (ES) technique has proven to be an effective and a versatile approach for crafting drug delivery carriers with diverse dimensions, multiple layers, and varying morphologies. Achieving the desired particle properties necessitates careful optimization of various experimental…
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Abstract This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to customizing dense bilayer medicines, our approach uses…
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The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot…
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This study comprises the comprehensive toxicological assessment of thiolated organosilica nanoparticles (NPs) synthesised from 3-mercaptopropyltrimethoxysilane (MPTS). We investigated the influence of three different types of nanoparticles synthesised from 3-mercaptopropyltrimethoxysilane: the…
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Abstract Risperidone is an antipsychotic drug classified as BCS Class II with low solubility at physiological pH and orally used in the treatment of schizophrenia. Electrospinning is one of the newest fabrication methods used for the development of fast soluble drug delivery systems. In this study,…
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The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a quality-by-design (QbD)-based paradigm. Utilizing Labrafil M 2125 CS, Kolliphor EL, and Transcutol P, the…
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See the new book, edited by Mine Orlu, Fang Liu Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients Details reasons for applying advanced pharmaceutical technologies for the benefit of the ageing population Discusses Advanced…
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See the new book, edited by Michael A. Repka, Nigel Langley Covers regulatory and manufacturing aspects of 3D printing in drug development Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D printing Thorough short text and guide for use on the…
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