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Drug Delivery
Inulin-based carriers for colon drug targeting
Inulin is a heterogeneous green polysaccharide obtained from natural sources. It is found in a variety of regularly eaten vegetables, fruits, cereals, and in their roots and rhizomes including onion, leek, wheat, garlic, dahlia, asparagus, banana, chicory, etc. It has been approved by the United…
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Enhancement of cytotoxicity of diallyl disulfide toward colon cancer by Eudragit S100/PLGA…
According to WHO cancer is the second leading cause of death globally, amounting to about 1 in 6 deaths. Among these, colon cancer is the third leading cause of mortalities worldwide. Current measures for cancer treatment: chemotherapy, radiation, and surgery are accompanied by myriad side effects.…
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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting…
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Microwave-induced in situ drug amorphization using a mixture of polyethylene glycol and…
The use of a mixture of polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) was investigated for microwave-induced in situ amorphization of celecoxib (CCX) inside compacts. Such amorphization requires the presence of a dipolar excipient in the formulation to ensure heating of the compact by…
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In vivo drug delivery via contact lenses: The current state of the field from origins to present
Over the past half century, contact lenses have been investigated for their potential as drug delivery devices for ocular therapeutics. Hundreds of studies have been published in the pursuit of the most effective and efficient release strategies and methods for contact lens drug delivery.
This…
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QbD Enabled Optimization of Solvent Shifting Method for Fabrication of PLGA Based Nanoparticles for…
The key objective of the current research was to fabricate and optimize Capecitabine loaded PLGA based nanoparticles (NPs) by enabling Quality by Design (QbD) approach for enhancing antitumor activity by promising delivery of the drug at the colonic site. The current research was based on…
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Natural gum polysaccharides as efficient tissue engineering and drug delivery biopolymers
The usage of plant origin natural gum polysaccharides in various biomedical applications is steadily rising in recent years because of their peculiar properties like biocompatibility, biodegradability, cytocompatibility and with no eliciting of immune response. The natural gums were used in various…
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Nanomaterials for Protein Delivery in Anticancer Applications
Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to…
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An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across…
Oral administration is the most commonly used route for drug delivery owing to its cost-effectiveness, ease of administration, and high patient compliance. However, the absorption of orally delivered compounds is a complex process that greatly depends on the interplay between the characteristics of…
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A modular device for vaginal administration of multiple therapeutic agents
In this project, the aim is to develop a new multipurpose prevention technology (MPT) platform to help address the global health burdens associated with sexually transmitted infections (e.g. HIV-1, HSV-2, HPV) and unmet need for contraception, which disproportionately affect young women in low and…
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