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Drug Delivery
Formulation and Evaluation of Naproxen Emulgel for Topical Delivery
Topical conveyance of medications can be accomplished by fusing drug into the gel network for viable conveyance of medications. NSAIDs are non-steroidal medications having superb mitigating and pain-relieving action however NSAIDs produces GIT ulceration, liver and kidney inconvenience particularly…
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Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug…
Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased…
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Melt extrusion deposition (MED™) 3D printing technology – A paradigm shift in design and development…
Three-dimensional printing (3DP) technology offers unique advantages for pharmaceutical applications. However, most of current 3D printing methods and instrumentations are not specifically designed and developed for pharmaceutical applications. To meet the needs in pharmaceutical applications for…
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Integrated in silico formulation design of self-emulsifying drug delivery systems
The drug formulation design of self-emulsifying drug delivery systems (SEDDS) often requires numerous experiments, which are time- and money-consuming. This research aimed to rationally design the SEDDS formulation by the integrated computational and experimental approaches. 4495 SEDDS formulation…
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Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery
Astaxanthin (ASX) is a potent lipophilic antioxidant derived from the natural pigment that gives marine animals their distinctive red-orange colour and confers protection from ultraviolet radiation. Self nano-emulsifying drug delivery systems (SNEDDS) have been successfully developed and evaluated…
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Carbomer microgels as model yield-stress fluids
The review presents current research results for Carbopol-based microgels as yield-stress materials, covering three aspects: chemical, physical and rheological. Such a joint three-aspect study has no analog in the literature. The chemical aspects of Carbopol polymers are presented in terms of a…
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A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of…
Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one drug in a single nanocomplex carrier could enhance the therapeutic potency and afford synergistic therapeutic effects.
In this study, we developed a novel…
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Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive…
The purpose of this study was to associate the poorly water-soluble antihypertensive drugs candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ) as fixed-dose combination, in the form of ternary Amorphous Solid Dispersions (ASD), using hydroxypropylmethylcellulose acetate succinate (HPMCAS) type…
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Tablet disintegration performance: Effect of compression pressure and storage conditions on surface…
The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and swelling behaviour of the tablet.
This study demonstrates the…
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Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness
The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual…
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