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Drug Delivery
The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid…
The aim of this work was to identify from a review of current literature the effects of lipids used in the development of Nanostructured Lipid Carriers (NLCs) on the physicochemical properties of the resulting formulation.
The size of the solid lipid, affected by the molecular weight and the…
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Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers
Capsules are a widely used oral dosage form due to their simplicity and ease of manufacture. They are equally popular for both pharmaceutical and nutraceutical products and since they do not need extensive formulation development, it is a dosage form of choice for new drugs undergoing animal or…
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Folic Acid Decoration of Mesoporous Silica Nanoparticles to Increase Cellular Uptake and Cytotoxic…
Breast cancer is the most frequent cancer among women and impacts over two million women each year. Although many different types of anticancer agents are available for breast cancer treatment, doxorubicin is one of the most widely used drug. However, doxorubicin related side effects such as heart…
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A Guide to Drug Development for Biologics: Overcoming Formulation and Manufacturing Challenges
What are Biologics?
A biopharmaceutical product (commonly referred to as a “biologic”) is defined as a pharmaceutical drug product manufactured in, extracted from, or semi-synthesized from biological sources. Biologics include vaccines, blood and blood components, allergenics, somatic cells, gene…
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Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
The increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial infection. Mtb has been shown to produce membrane-derived…
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Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products. These advantages include better specificity, potency, targeting abilities, and reduced side effects. Despite the…
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Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel…
The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer) and glycyrrhizic acid to improve solubility, bioavailability, and anti-hyperuricemic activity of aloe emodin (AE). The AE-loaded…
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Effects of Solvents, Emulsions, Cosolvents, and Complexions on Ex Vivo Mouse Myometrial…
A great need exists to develop tocolytic and uterotonic drugs that combat poor, labor-related maternal and fetal outcomes. A widely utilized method to assess novel compounds for their tocolytic and uterotonic efficacy is the isometric organ bath contractility assay. Unfortunately, water-insoluble…
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Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of…
Alginates are biopolymers that have been investigated for their use in food and medical fields. Minimal information is available regarding their potential application as tablet superdisintegrants. Here we studied the disintegration action of sodium alginate (SA), calcium alginate (CA) and alginic…
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Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and…
Veklury™ by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing…
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