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Drug Delivery
Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population. The main PD hallmarks include the loss of dopaminergic…
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Nanostructured lipid carriers for enhanced in vitro and in vivo schistosomicidal activity of…
WHO considers praziquantel (PZQ) as the drug of choice for treatment of Schistosoma mansoni infection but this requires high dose due to poor solubility and first pass metabolism. The aim of this work was to optimize nanostructured lipid carriers (NLCs) for enhanced PZQ oral delivery. The…
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Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers. Among the applications of nanocarriers, drug delivery to the skin has attracted increasing attention in recent decades due to its advantages over…
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Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic…
Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient self-administration and hence long-term chronic…
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The evolution of commercial drug delivery technologies
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small…
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How Cellets’ particle size influences the flow behavior in a Wurster fluid-bed coater
Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial parameters. Additionally, high level of robustness and…
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Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid…
The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid lipid nanoparticles (SLN) as a controlled-release film onto a…
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Ocular Implants for Drug Delivery: Improving Patient Outcomes
Did you know that there are already 11 ocular implants on the market and over 30 in development? (See Table 1 and Figure 2). Every year, more and more people live with eye disease or vision impairment of some kind, requiring treatment to avoid additional vision loss or blindness.
In 2010,…
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Mathematical Modeling of Release Kinetics from Supramolecular Drug Delivery Systems
Winner of the Pharmaceutics 2021 Best Paper Awards
Embedding of active substances in supramolecular systems has as the main goal to ensure the controlled release of the active ingredients. Whatever the final architecture or entrapment mechanism, modeling of release is challenging due to the moving…
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Sustained release of peptides and proteins from polymeric nanocarriers produced by inverse Flash…
Peptide and protein therapeutics generally exhibit high potency and specificity and are increasingly important segments of the pharmaceutical market. However, their clinical applications are limited by rapid clearance and poor membrane permeability. Encapsulation of the peptide or protein into a…
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