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Drug Delivery
Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary…
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing process conditions.
In this study, compaction of API…
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Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with…
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two or more (initially crystalline) low molecular weight components that form a homogeneous single-phase amorphous system. Over the past decades, CAMS have been widely investigated as a promising approach to address…
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Novel formulations and drug delivery systems to administer biological solids
Recent advances in formulation sciences have expanded the previously limited design space for biological modalities, including peptide, protein, and vaccine products. At the same time, the discovery and application of new modalities, such as cellular therapies and gene therapies, have presented…
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Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation…
The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers. The phase solubility measurement for the supplied FFH…
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Transferrin-functionalized lipid nanoparticles for curcumin brain delivery
Curcumin is an anti-inflammatory and antioxidant compound with potent neuroprotective activity. Due to its poor water solubility, low bioavailability, rapid elimination and the challenges for crossing and transposing the blood-brain barrier (BBB), solid lipid nanoparticles (SLNs) and nanostructured…
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Comparative evaluation study of polycomplex carriers based on Eudragit® EPO/S100 copolymers prepared…
Interpolymer complexes (IPC) Eudragit® EPO/S100 were prepared in different media (water pH of 7.0 and ethanol). According to the elemental analysis, FTIR spectroscopy, and thermal analysis data, IPC prepared in aqueous media (denoted as interpolyelectrolyte complexes—IPECs) is stabilized…
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Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route
Self-microemulsifying drug delivery systems (SMEDDSs) have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules. However, information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is rare.…
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Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics
After additive manufacturing of pharmaceuticals has been introduced as viable method to produce individualized drug delivery systems with complex geometries and release profiles, semi-solid micro-extrusion has shown to be uniquely beneficial. Easy incorporation of actives, room-temperature…
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High Acceptability of an Orally Dispersible Tablet Formulation by Children
There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient.…
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Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: ex vivo and in vivo Studies
The objective of this investigation was to formulate chitosan coated, insulin-loaded solid lipid nanoparticles (SLN) for oral administration and investigate their potential as an effective alternative to the subcutaneous injection.
Methods: The SLN were prepared from glyceryl monostearate and…
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