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Drug Delivery
Enabling Oral Amphotericin B Delivery by Merging the Benefits of Prodrug Approach and…
Amphotericin B (AmB) is gold standard therapy for leishmaniasis and fungal infections. Considering the global disease burden, nearly 90% of cases occur in economically vulnerable countries, making the cost of AmB therapy a critical healthcare challenge in controlling disease burden. All currently…
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Nanoemulsion-based patch for the dermal delivery of ascorbic acid
Photo-aging is caused mainly by sun radiations, which consist mainly of the ultraviolet radiation (UVA and UVB). Ascorbic acid (AA) has been widely used in the cosmetic field as an anti-wrinkle, anti-pigmentary, and antioxidant agents, however, its cosmetic application is limited due to its poor…
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In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for…
In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive…
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Microemulsion-Based Media in Nose-to-Brain Drug Delivery
Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered intranasally can be delivered directly to the central nervous system.…
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Brittle polymers in Fused Deposition Modeling: An improved feeding approach to enable the printing…
Brittleness is often described as a restricting material property for the processability of filaments via Fused Deposition Modeling. Especially filaments produced from approved pharmaceutical polymers often tend to fracture between feeding gears, the commonly employed feeding mechanism. In order to…
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ExciPerience 2021- The complete overview and explanation of the new event for pharmaceutical…
What is the ExciPerience?
ExciPerience 2021 was the new virtual event around every aspect of pharmaceutical excipients. ExciPerience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It was the intersection between all the different perspectives…
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Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of…
Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process. However, quantitative prediction of oral absorption from…
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Electrosprayed mucoadhesive alginate-chitosan microcapsules for gastrointestinal delivery of…
Besides viability protection, a sufficiently prolonged gastrointestinal retention of probiotics has emerged as critically important in improving the functional effectiveness of gastrointestinal delivery of these microorganisms. In this work, we formulated pure, resistant starch-reinforced and…
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Exploring the Interplay between Drug Release and Targeting of Lipid-Like Polymer Nanoparticles…
Targeted delivery of doxorubicin still poses a challenge with regards to the quantities reaching the target site as well as the specificity of the uptake. In the present approach, two colloidal nanocarrier systems, NanoCore-6.4 and NanoCore-7.4, loaded with doxorubicin and characterized by different…
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Formulation and optimisation of lamivudine‐loaded Eudragit® S 100 polymer‐coated pectin microspheres…
This investigation is to find a prolonged or delayed drug release system, exclusively for the treatment of hepatitis‐B to reduce the side effects, which arise when conventional solid dose forms are administered. To pursue this goal, lamivudine‐loaded Eudragit‐coated pectin microspheres have been…
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