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Drug Delivery
Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production…
Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. At the same time, modern technologies are…
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Microemulsion-Based Media in Nose-to-Brain Drug Delivery
Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered intranasally can be delivered directly to the central nervous system.…
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Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring
The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition. In vivo relevant incubation conditions have been shown to…
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A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation,…
Treatment of posterior uveitis via topical route is desirable but cannot be achieved by conventional drug delivery strategies. Therefore, the aim of this study is to develop a topical nanomicellar formulation of an immunosuppressant drug, everolimus using Soluplus®, a grafted copolymer of polyvinyl…
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Effects of polyvinylpyrrolidone (K90) on membrane permeation via the transcellular route in the rat…
Although pharmaceutical excipients do not affect the membrane permeation of active drugs, some have been shown to influence absorption-regulating factors. However, limited information is currently available on the effects of pharmaceutical excipients on membrane permeation via passive transcellular…
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Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific…
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically.
Here, we report a generalizable…
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Powder Properties and Flowability Measurements of Tailored Nanocomposites for Powder Bed Fusion…
The modification of metal alloy powders by coating with nanoparticles offers the possibility to improve additive manufacturing processes, in particular the powder bed fusion of metals with laser beams (PBF/LB-M), from the material side of view. Subsequently, component qualities including mechanical…
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Quaternary polymethacrylate−magnesium aluminum silicate film formers: Stability studies for tablet…
The objective of this work was to investigate the long-term stability of quaternary polymethacrylate-magnesium aluminum silicate (QPM-MAS) nanocomposite film-coated tablets compared to that of QPM-coated tablets. QPM- and QPM-MAS-coated tablets prepared without or with a curing process at 60 °C for…
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Advanced applications of green hydrogels in drug delivery systems
Hydrogels are the versatile three-dimensional (3D), crosslinked polymeric networks that have demonstrated numerous vital functions in several scientific domains.
Various inherent, structural features of hydrogels have fascinated the formulation scientists working on drug delivery and potential…
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Characterization and Applications of Colloidal Systems as Versatile Drug Delivery Carriers for…
Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available to enhance water solubility, but this alone does not entail…
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