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Drug Delivery
Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus…
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes between cells and their natural affinity to target cells. Their intrinsic features such as stability,…
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent…
The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially…
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Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS diseases, having major role in the protection of the brain but…
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Ibuprofen-loaded calcium phosphate granules: A new bone substitute for local relieving symptoms of…
Musculoskeletal diseases often demand a drug treatment at the specific site of injury or defect site. In this context, the use of calcium phosphates is attractive as it allows both the bone substitution and the local delivery of a drug substance. In this work, we present a drug delivery device that…
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Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and…
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients. In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast X-ray…
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Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress
Global cancer prevalence has continuously increased in the last decades despite substantial progress achieved for patient care. Cancer is no longer recognized as a singular disease but as a plurality of different ones, leading to the important choice of the drug administration route and promoting…
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3D printing of patient-tailored SNEDDS-based suppositories of lidocaine
Personalized drug delivery systems are considered an interesting perspective of the 3D printing technology, with the potential to counterbalance the pharmacological and adverse effects of pharmaceutical products. Our study was focused on the utilization of the pressure-assisted microsyringes…
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Understanding the role of colon-specific microparticles based on retrograded starch/pectin in the…
The encapsulation of nanoparticles within microparticles designed for specific delivery to the colon is a relevant strategy to avoid premature degradation or release of nanoparticles during their passage through the stomach and upper gastrointestinal tract (GIT), allowing the targeted delivery of…
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Engineering precision nanoparticles for drug delivery
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental and cellular — that are heterogeneous across…
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