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Drug Delivery
Development of pH-sensitive vaginal films based on methacrylate copolymers for topical HIV-1…
Interest is growing in “smart” vaginal microbicides as a strategy to protect women from sexual transmission of human immunodeficiency virus (HIV). The concept is based on the development of products featuring low drug release in acidic media such as vaginal fluid but switch to a fast release…
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Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion
Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles
Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin.
The role of EVs and their contents, including RNA,…
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Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
Purpose
Drug X is high solubility, high permeability BCS/DCS I small molecule drug.
High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam
The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing microcrystalline cellulose, lactose monohydrate, and…
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Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical…
The complexity of hard‐to‐treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The…
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Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal…
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding…
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Controlled Delivery of Bile Acids to the Colon
Bile acids, such as chenodeoxycholic acid, play an important role in digestion but are also involved in intestinal motility, fluid homeostasis, and humoral activity. Colonic delivery of sodium chenodeoxycholate (CDC) has demonstrated clinical efficacy in treating irritable bowel syndrome with…
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Long-Acting Drug Delivery: Injections, Implants, and Combination Products
Combination products and drug delivery devices aid in patient compliance and a movement toward point-of-care at home. In this article, Nick DiFranco, Market Manager – Long-Acting Drug Delivery and Combination Products, discusses trends in the market for long-acting injectables, long-acting…
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