Drug Delivery

Parenteral drug delivery plays a very vital role in pharmacotherapy of various acute and critical illnesses. Injectables have been preferred formulations over oral and topicals especially in case where rapid effects of drugs are required or prolongation of drug release is desired. This would not…
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The present research work involves Quality by Design (QbD)-based fabrication of lipid nanoconstructs (LNC) of paliperidone (PPD) bearing superior biopharmaceutical attributes. Highlights Lipid nanoconstructs (LNC) is a potential carrier for augmenting the solubility and bioavailability of the…
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Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Polymeric inserts containing azithromycin-loaded Eudragit® L100 nanoparticles were developed to sustain the drug release and enhance its ocular performance. The solvent diffusion technique was employed to prepare nanoparticles. The developed nanoparticles (NPs) were fully characterized and…
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Liposomes, nanoemulsions and polymeric nanoparticles have all shown promise in improving the therapeutic benefits of cannabinoids, but the full potential of these therapies has not yet been unlocked. Nanotechnology for active pharmaceutical ingredients (APIs), in this case cannabis compounds, is the…
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PLGA nanoparticles hold great promise for nasal administration, but only with careful design will efficient, effective, and safe delivery systems be developed. To better understand the size dependence of nasal epithelial uptake, PLGA nanoparticles (60 nm or 125 nm) loaded with Nile Red were prepared,…
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Hydrochlorothiazide (HCTZ) is a class IV BCS drug that exhibits varying bioavailability due to poor solubility and low permeability. The first part of the present investigation was aimed to prepare liquid self-microemulsifying drug delivery system (SMEDDS) of HCTZ to improve its dissolution…
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The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids. Methods Pediatric hydrocortisone granules were studied using a biopredictive in vitro approach. Experiments included an in…
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Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due to their degradation in the gastrointestinal tract and low transmucosal permeation. In this study, the concept of an oral delivery device utilizing an elastomeric material is…
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Systems composed of bioadhesive and thermoresponsive polymers can combine in situ gelation with bio/mucoadhesion, enhancing retention of topically applied drugs. The effect of bioadhesive sodium carboxymethylcellulose (NaCMC) and hydroxypropyl methylcellulose cellulose (HPMC) on the properties of…
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