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Drug Delivery
Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on…
Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their size and its properties, solid lipid nanoparticles as drug delivery carrier have shown…
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Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid…
It has been previously claimed that miconazole (MNZ) has activity against Plasmodium falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an alternative antimalarial agent. MNZ was entrapped in nanostructured lipid carriers (NLC) based on Softisan®154 and soybean oil…
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Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Storage stability of proteins in a liquid-based formulation: liquid vs. solid self-emulsifying drug…
The objective of the present study was the development of self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins providing storage stability. Horseradish peroxidase (HRP) serving as model protein was ion paired with docusate and incorporated into three liquid and…
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Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone)…
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20…
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Successful Drug Development with Synthetic Lipids: Critical Aspects and Strategies
pharma's almanac - September 29, 2020 PAP-Q3-20-CL-024 - Shiksha Mantri, Ph.D. - Adela Kasselkus, Ph.D.
Lipid-based drug delivery systems offer several advantages, including improving the stability, solubility, bioavailability, and toxicity profiles of active pharmaceutical ingredients (APIs). It…
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Oral raft forming in situ gelling system for site specific delivery of calcium
In situ gelling Raft forming system (GRFS), a novel sol-gel system of calcium carbonate (CC) was developed with the aim to prolong the gastric residence time and thereby the bioavailability. A simple lattice mixture design was adopted to study the effect of formulation composition (% HPMC K100 M and…
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Types and evaluation of in vitro penetration models for buccal mucosal delivery
Oral buccal mucosal delivery has the advantage of avoiding gastrointestinal drug degradation, reducing hepatic firstpass effects, and improving patient compliance. In recent years, it is becoming a drug delivery route that researchers have paid attention to. One of the major constraints to bringing…
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6 reasons why to use sugar spheres
Learn more about the use of sugar spheres in this video from pharm-a-spheres™.
Sugar spheres (also called neutral pellets, nonpareil seeds, microgranules or sugar beads) are produced, preferably using a layered sugar-coating structure. The result is sugar spheres with sufficient mechanical…
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Role of Polymer Physicochemical Properties on in vitro Mucoadhesion
Polymers with mucoadhesive properties are universally used in the development of mucoadhesive drug delivery system. Their physicochemical properties as well as the mechanisms related to their adhesive actions draw great attention for the modification of mucoadhesive properties.
In this study,…
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