Drug Delivery

The poor aqueous solubility of drugs challenges their pharmaceutical development and oral bioavailability. At present, the development of dosage forms with poorly water-soluble drugs by means of amorphous solid dispersions (ASDs) approach has been an active area of research. Meanwhile, dielectric…
Read More...

The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques. Methods SRSD-CAR containing different ratios of polymers were prepared…
Read More...

Abstract-Introduction: The current research is aimed at formulating and evaluating fluvastatin self-nanoemulsifying drug delivery system (SNEDDS). Materials and Methods: Fluvastatin SNEDDS formulated using sefsol-218 (oil), Cremophor RH40 (surfactant), and propylene glycol…
Read More...

Pickering emulsions are surfactant-free emulsions stabilized by solid particles. Their unique structure endows them with good stability, excellent biocompatibility, and environmental friendliness. Pickering emulsions have displayed great potential in oral drug delivery. Highlights • …
Read More...

Scaling up fluidised bed coating of microparticles with particle size smaller than 150 µm is a challenge because of the high tendency of particle agglomeration. Consequently, the production yield of coating trials are unsatisfactory and low spray rate is typically applied leading to long duration of…
Read More...

As a result of its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research of growing interest. Developing new pharmaceutical…
Read More...

Pharmaceutical 3D-printing represents a potentially new dosing and manufacturing approach for the pharmaceutical industry, with unique opportunities for personalization of dosage strengths. Fused deposition modelling (FDM) is a 3D-printing technique, which presents advantages for decentralized…
Read More...

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the treatment options still represent stability concerns since…
Read More...

Pharmaceutical drugs are an important part of the global healthcare system, with some estimates suggesting over 50% of the world's population takes at least one medication per day. Most drugs are delivered as immediate-release formulations that lead to a rapid increase in systemic drug…
Read More...

Considering microneedles (MNs) as transdermal drug delivery tools is driven by some crucial factors among which easy handling, simple administration and better patient compliance are primary. Achievable tailored microneedle production allowing encapsulation of range of pharmaceuticals and…
Read More...