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Drug Delivery
Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its…
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic regimen of acyclovir is associated with unwarranted adverse…
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Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
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Use of calcium carbonate as an excipient for release of poorly water soluble drugs: The case of…
Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the effects of CaCO3 on the physicochemical properties of CBZ and its…
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Preparation, optimization and preliminary pharmacokinetic study of curcumin encapsulated turmeric…
The present investigation aimed to develop curcumin loaded turmeric oil microemulsion for brain targeting. An effort has been made to investigate the role of functional components in developing brain targeted formulation which could enhance the bioavailability and uptake of drug in the brain upon…
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Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of enteric semipermeable capsule shell and the core prescription…
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Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and…
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential…
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Impact of Reverse Micelle Loaded Lipid Nanocapsules on the Delivery of Gallic Acid into Activated…
Gallic acid (GA) is a polyphenolic compound with proven efficacy against hepatic fibrosis in experimental animals. However, it suffers from poor bioavailability and rapid clearance that hinders its clinical investigation. Accordingly, we designed and optimized reverse micelle-loaded lipid…
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Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of…
Graphene oxide (GO) is an amphiphilic, high surface area material with great potential as a functional excipient in drug delivery. The present study aimed at incorporating GO in buccal polyelectrolyte films for delivery of antifungal drugs and investigating the effect of GO on the film properties…
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Mechanisms of Water Permeation and Diffusive API Release from Stearyl Alcohol and Glyceryl Behenate…
This work aims to develop complimentary analytical tools for lipid formulation selection that offer insights into the mechanisms of in-vitro drug release for solid lipid MR excipients. Such tools are envisioned to aide and expedite the time consuming process of formulation selection and development.…
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Fused deposition modeling of API-loaded mesoporous magnesium carbonate
In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. Cinnarizine, a BCS class II drug, was loaded into the pores of the mesoporous material via a soaking method,…
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