Drug Delivery

Lipid-based drug delivery systems have been used as a useful tool for the formulation of hydrophobic drugs giving us the opportunity to enhance permeation from biological membranes, protecting active ingredients from harsh in vivo environment, thus enhancing the bioavailability. Self-emulsifying…
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Despite being the most effective hypolipidemic agent, poor physicochemical properties of Rosuvastatin calcium (RCa) remain challenging obstacles in the development of pharmaceutical dosage forms. Inclusion complexes (ICs) of RCa with cyclodextrin (CD) derivatives; methyl-beta-cyclodextrin (M-β-CD)…
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Peptide and protein drugs (PPDs) that possess the advantages of high specificity and tolerance, and low immunogenicity can effectively treat diabetes, osteoporosis, cancer, and genetic defects. However, the high molecular weight and poor stability of PPDs lead to low bioavailability in oral delivery…
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Ultra-small nanostructured lipid carriers (usNLCs) have been hypothesized to promote site-specific glioblastoma (GB) drug delivery. Envisioning a multitarget purpose towards tumor cells and microenvironment, a surface-bioconjugated usNLC prototype is herein presented. The comeback of co-delivery by…
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The purpose of this study is to investigate the process of drug distribution and mechanism of drug release of ophthalmic emulsions in the context of factors associated with the drug release. Cyclosporine and difluprednate emulsions were chosen as model systems. Highlights • The process of…
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One of the main problems with NSAIDs is the dosing frequency, which leads to patients’ noncompliance. To overcome this, fabrication of sustained release formulation of the drug is considered a well-reputed technique. The present study aimed to develop sustained release formulation of a model drug…
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Cancer is considered as one of the biggest threats to human worldwide. Researchers suggest that tumour is not just a single mass, it comprises cancerous cells surrounded by noncancerous cells such as immune cells, adipocytes, and cancer stem cells (CSCs) in the extracellular matrix (ECM) contains…
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So much for capsules can only be filled with powders, pellets, microtablets or liquids! The Accordion Pill® by Intec Pharma Ltd. is a drug delivery system that uses active ingredient containing polymeric films, which are folded into an undulated shape. This system combines an efficient gastric…
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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of dierent…
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Nanoparticles with reduced crystallinity are normally produced by bottom-up (precipitation) processes; however, the drug loading can be limited. The objective was to generate such nanoparticles using modified drugs coupled with high pressure homogenization (HPH) and investigate the coeffects of…
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