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Drug Delivery
Polymeric Systems for the Controlled Release of Flavonoids
Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively…
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Apisolex™ Polymer – by Lubrizol
Solubility-enhancing polymer for use in bolus injections and IV infusions
Lubrizol Life Science Health’s (LLS Health’s) Apisolex™ GMP, injectable-grade excipient is a safe, polyamino acid-based polymer that enhances the solubility of BSC Class II and IV APIs.
Formulation Benefits…
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Enhancing the oral drug delivery through hot melt extrusion techniques
Hot melt extrusion has been developed as a fresh technique for taste masking, in recent years. This method provides many aids as compared to traditional methods like avoiding the use of solvents, continuous manufacturing, ease to scale up, and adaptability to meet the goals of FDA for quality…
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The Future of Drug Delivery
Drug delivery technologies have been proven to improve treatment outcomes in many ways, including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance, and enabling entirely new medical treatments. As the therapeutic landscape has evolved from small-molecule drugs to a…
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Composition-Property Relationships of pH-Responsive Poly[(2-vinylpyridine)-co-(butyl methacrylate)]…
The taste-masking of bitter-tasting active pharmaceutical ingredients is key to ensuring patient compliance when producing oral pharmaceutical formulations. This is generally achieved via the incorporation of pH-responsive, reverse enteric polymers, that prevent the dissolution of the formulation in…
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Drug delivery as a sustainable avenue to future therapies
Climate change and the need for sustainable, technological developments are the greatest challenges facing humanity in the coming decades. To address these issues, in 2015 the United Nations have established 17 Sustainable Development Goals. Anthropogenic climate change will not only affect everyone…
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Development of multifunctional drug delivery system via hot-melt extrusion paired with fused…
The model of core–shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery. Through the encapsulation of the drug by the outer shell, this model exhibits huge potential for reduced administration frequency, improved…
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Orally disintegrating drug carriers for paediatric pharmacotherapy
Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several…
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Investigation of In Vivo Bioavailability Enhancement of Iloperidone-Loaded Solid…
Purpose
The current research focuses on enhancement of in vitro dissolution and in vivo bioavailability characteristics of iloperidone (IP) by formulation, optimization of L-SNEDDS using Box-Behnken design (BBD), and desirability function. L-SNEDDS were transformed into free-flowing powders by…
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A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of…
The aim of this study was to develop, characterize and evaluate the in vivo oral efficacy of self-emulsifying drug delivery systems (SEDDS) containing fexinidazole (FEX) in the experimental treatment of visceral leishmaniasis (VL). The developed FEX-SEDDS formulation presented as a clear, yellowish…
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